Noni fruit juice reverses the adverse effects of 3-Methyl-4-Nitrophenol in rat spleen

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dc.contributor.authorESENER, Osman Behzat Buraken_US
dc.contributor.authorY???T, Fundaen_US
dc.contributor.authorGÜREV?N, Ebru GÜRELen_US
dc.contributor.authorSÖNMEZ, K?v?lc?men_US
dc.contributor.authorYILMAZER, Nadimen_US
dc.contributor.authorAKTA?, Abiten_US
dc.contributor.authorDA?LIO?LU, Suzanen_US
dc.contributor.authorYERL?, Ozanen_US
dc.contributor.authorDÖLEK, Mehmet Sefaen_US
dc.contributor.authorARMUTAK, Elif ?lkayen_US
dc.date.accessioned2025-08-13T11:23:11Z
dc.date.available2025-08-13T11:23:11Z
dc.date.issued2025-06
dc.description.abstractNoni plant is recognized for its antioxidant properties and broad therapeutic effects. 3-Methyl-4-Nitrophenol (PNMC) poses toxic effects on various organs. This study aimed to investigate the effects of PNMC, a substance to which both animals and humans are exposed through diesel exhaust particles and widely used pesticide fenitrothion, on the number of plasma cells in the spleen and also whether Noni could alleviate PNMC-induced spleen damage in rats by assessing spleen index, plasma cell counts, and levels of TNF-? and iNOS. Eight rat groups were treated with different doses of PNMC, either alone or combined with Noni, or only Noni, or vehicle (PBS with 0.05% Tween 80, s.c.) for five days. In histological analysis, plasma cells were counted in methyl green-pyronin stained sections, and TNF-? and iNOS levels were assessed immunohistochemically. PNMC exposure significantly reduced (P <0.001) plasma cell counts in the spleen, while Noni reversed this effect, particularly in the 10 mg/kg PNMC group. Noni caused a statistically insignificant decrease (P <0.05) in the TNF-? index in the 1 mg/kg PNMC group. A significant rise (P <0.001) in iNOS levels was observed in the 100 mg/kg PNMC+Noni group, while the 1 mg/kg PNMC+Noni combination significantly reduced (P <0.001) iNOS values. These findings indicate that the inflammatory response to PNMC and its modulation by Noni are dose-dependent. Notably, Noni restored plasma cell counts in inflamed spleen to levels comparable to the control group, suggesting its protective potential in PNMC-induced spleen damage.en_US
dc.identifier.affiliationsDepartment of Histology and Embryology, Faculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsDepartment of Histology and Embryology, Faculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsDepartment of Biology, Faculty of Science, ?stanbul University, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsDepartment of Pathology, Faculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsDepartment of Biology, Faculty of Arts and Sciences, Tekirda? Nam?k Kemal University, Tekirda?, Türkiyeen_US
dc.identifier.affiliationsDepartment of Histology and Embryology, Faculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsDepartment of Histology and Embryology, Faculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsFaculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsFaculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.affiliationsDepartment of Histology and Embryology, Faculty of Veterinary Medicine, ?stanbul University-Cerrahpa?a, ?stanbul, Türkiyeen_US
dc.identifier.citationESENER Osman Behzat Burak, Y???T Funda, GÜREV?N Ebru GÜREL, SÖNMEZ K?v?lc?m, YILMAZER Nadim, AKTA? Abit, DA?LIO?LU Suzan, YERL? Ozan, DÖLEK Mehmet Sefa, ARMUTAK Elif ?lkay . Noni fruit juice reverses the adverse effects of 3-Methyl-4-Nitrophenol in rat spleen . Indian Journal of Experimental Biology. 2025 Jun; 63(6): 465-472en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253763
dc.languageenen_US
dc.publisherThe India Publications and Information Directorate (CSIR-NISCAIR)en_US
dc.relation.issuenumber6en_US
dc.relation.volume63en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v63i06.14546en_US
dc.subjectDiesel exhaust particlesen_US
dc.subjectPesticideen_US
dc.subjectMorinda citrifoliaen_US
dc.subjectPlasma cellen_US
dc.subjectRaten_US
dc.subjectSpleen indexen_US
dc.titleNoni fruit juice reverses the adverse effects of 3-Methyl-4-Nitrophenol in rat spleenen_US
dc.typeJournal Articleen_US
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