Assessment of Thyroid Disorder in FarWestern Part of Nepal: A Hospital Based Study.
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Date
2012-10
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Abstract
Objectives: This study was conducted to know the status of thyroid disorder in people of far western region
of Nepal. Methods: A total of 808 cases, out of which 133 male and 675 female were included and study
was carried out using data retrieved from the register maintained in the Department of Biochemistry of the
Nepalgunj Teaching Hospital, Kohalpur, Banke, Nepal, between 1st January, 2011 and 28th February, 2012.
The variables collected were age, sex, and thyroid function profile including free T3, free T4 and TSH. The
data was analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows
Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results: The percentage
of thyroid disorders was 33.66% in people of far western region of Nepal. The people were highly affected
by overt hyperthyroidism (14.9%) followed by subclinical hyperthyroidism (9.9%). The subclinical
hypothyroidism was 7.9% while 1% overt hypothyroidism only. Serum fT3, fT4 and TSH level were significantly
different in male and females. Similarly, fT3, fT4 and TSH levels show statistically significant differences
in different thyroid disorders. The fT3 and fT4 level in overt hyperthyroidism and subclinical
hypothyroidism showed statistically significant differences when compared with euthyroidism group.
Likewise, TSH level also shows statistically significant in all the thyroid disorders when compared with
euthyroidism group. The fT3 and fT4 levels were statistically insignificant in all the age groups whereas
TSH level showed statistically significant different in all the age groups. The fT3 and fT4 level in 21-40
years showed statistically significant when compared with serum level of fT3 and fT4 of 0-20 years.
Similarly, serum level of TSH in 21-40 and 41-60 years also showed statistically significant when compared
with serum level of TSH of 0-20 years. Conclusion: The people residing in far western region have risk for
thyroid disorders. They were suffering with thyroid disorder, especially overt hyperthyroidism (14.9%) and
subclinical hyperthyroidism (9.9%). Further studies are required to characterize the reasons for this high
prevalence of overt hyperthyroidism and subclinical hyperthyroidism.
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Keywords
Free T3, Free T4, TSH, Hyperthyroidism, Hypothyroidism, Nepal
Citation
Yadav N K, Thanpari C, Shrewastwa M K, Mittal R K, Koner B C. Assessment of Thyroid Disorder in FarWestern Part of Nepal: A Hospital Based Study. Bangladesh Journal of Medical Science. 2012; 11(4): 303-306.