Calcium and Phosphorus Metabolism in Patients with Congestive Heart Failure: A Cross-Sectional Study
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Date
2023-04
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Publisher
Ibn Sina Academy of Medieval Medicine & Sciences
Abstract
Background: To study the role of calcium and phosphorus metabolism including the hormones (Vitamin D and PTH) controlling them in patients with congestive heart failure. While extensive studies are available regarding bone mineral metabolism in CKD patient with regard to CVD / HF similar studies in non-CKD patients are sparce, hence the present study. Methods: A cross sectional study was done on a total of 50 patients with signs, symptoms and Echocardiographic findings suggestive of heart failure admitted in medicine wards of Government Medical College Patiala. Patients with type 2 diabetes mellitus, chronic renal disease, thyroid disease and pregnant/lactating mothers were excluded from the study. Serum calcium, phosphorus, Vitamin D and parathyroid hormone were estimated in all patients. Results: The study population consisted of 54% males, 46% females. Mean age was 61.78 +/- 9.18 years. Majority of the patients had cardiac ejection fraction in the range of 22-28%. CAD and HT were present in 58% and 66% patients respectively. Mean values for Vitamin D levels were 19.5 ng/ml. While in patients with normal ejection fraction Vitamin D levels was 29.34ng/ml, it progressively decreased with decreasing ejection fraction, patients with ejection fraction of <20% had Vitamin D levels of 8.98 ng/ml. Similarly mean value of PTH was 89.07 pg/ml and progressively increased with decreasing ejection fraction. Maximum valve of 138.27 pg/ml was found in patients with ejection fraction of <20%. Serum phosphorus value progressively increased with decreasing ejection fraction. Similar trends were found for serum calcium levels also. Conclusion: There is an association between congestive heart failure and calcium and phosphorus metabolism (along with their controlling hormones Vitamin D and parathyroid hormones). Rising levels of phosphorus and PTH and decreasing levels of Vitamin D are directly related with progressive heart failure.
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Keywords
Calcium, Phosphorus, Metabolism, Congestive Heart Failure
Citation
Chander Vikas, RPS Sibia, Makkar Gurjeen Kaur, Singh Manjinder, Garg Parteek, Dua Jasmeen Kaur . Calcium and Phosphorus Metabolism in Patients with Congestive Heart Failure: A Cross-Sectional Study. International Journal of Medical Research Professionals. 2023 Mar; 9(2): 25-29