Assessment Of Serum Paraoxonase-1 Enzyme Activity, Malondialdehyde And Vitamin-c In Oral Premalignancies

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dc.contributor.authorParam, Karen_US
dc.contributor.authorKanchan, Mohoden_US
dc.contributor.authorPuttewar, Manishen_US
dc.contributor.authorKumar, Satishen_US
dc.date.accessioned2020-05-05T07:06:11Z
dc.date.available2020-05-05T07:06:11Z
dc.date.issued2018-07
dc.description.abstractBackground:Oral premalignancies are a group of disease or syndromes which if left untreatedcanleadtocancer.ItcarriesagreatsignificanceinIndianperspective. Theactual figure of oral cancers arising from oral premalignancies is not known and to predict accuratelythemalignanttransformationsofthemisstillnotpossible.Oxidativestressisa known player behind cancerogenesis. Recently decreased Paraoxonase-1 activity and increasedoxidativestressmarkerswarefoundtobeassociatedwithOralSquamousCell Carcinoma. So, thereis astrongpossibilityofasimilar findingin Oral Premalignanciestoo. Aim: This studyaims to investigatethecor-relation between serum PON-1 activityand oxidative stress markers (MDA& Vitamin C) in patients with Oral Premalignancies. MaterialandMethods:Atotalof62patientswithclinically diagnosedoralpremalignant lesions anddiseasedcontrolswerechosenforthe study. Venous bloodsampleswerecollectedandPON-1,MDA (inse-rum)&Vitaminc (inplasma) wereanalysed spectro-photometrically. Results:A significant decreased serum PON-1 activity (P<0.05) and concomitant significantlyincreased serum MDA(P<0.05)anddecreased Vitamin Clevels (P<0.05) were observedinpremalignanciescomparedtothecontrols.Thesefinding weremorepronounced inOral Leukoplakia (OL) thaninOral Submucous Fibrosis (OSMF)withasignificantdifference.Meanlevelsoftheanalysedparameters differedaccordinglyin theclinicalgrades of oral premalignancies. Conclusion:Itcanbeenvis-agedthatserumPON-1activity andincreasedoxidativestress mightbe acontributingfactorbehindpathogenesisandprogressionofOralPremalignant Diseasesen_US
dc.identifier.affiliationsDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of ENT, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, Indiaen_US
dc.identifier.citationParam Kar, Kanchan Mohod, Puttewar Manish, Kumar Satish . Assessment Of Serum Paraoxonase-1 Enzyme Activity, Malondialdehyde And Vitamin-c In Oral Premalignancies. International Journal of Clinical and Biomedical Research. 2018 Jul; 4(3): 21-26en_US
dc.identifier.issn2395-0471
dc.identifier.issn2521-0394
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200814
dc.languageenen_US
dc.publisherSumathi Publicationsen_US
dc.relation.issuenumber3en_US
dc.relation.volume4en_US
dc.source.urihttps://www.doi.org/10.31878/ijcbr.2018.43.05en_US
dc.subjectPremalignanciesen_US
dc.subjectCancerogenesisen_US
dc.subjectPON-1en_US
dc.titleAssessment Of Serum Paraoxonase-1 Enzyme Activity, Malondialdehyde And Vitamin-c In Oral Premalignanciesen_US
dc.typeJournal Articleen_US
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