Studies on regulation of chorionic gonadotropin secretion in primates.

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dc.contributor.authorRao, A Jagannadha
dc.contributor.authorMathialagan, N
dc.contributor.authorKotagi, S G
dc.contributor.authorMoudgal, N R
dc.date.accessioned2015-07-23T08:41:42Z
dc.date.available2015-07-23T08:41:42Z
dc.date.issued1984-07
dc.description.abstractThe regulation of secretion of chorionic gonadotropin in primates has been studied using both in vivo and in vitro models. In vivo studies using the pregnant bonnet monkey revealed that at the doses tested, the administration of progesterone or estradiol 17β in combination or alone did not result in any appreciable change in the duration or magnitude of serum chorionic gonadotropin levels. However, administration of lutropin-releasing hormone by intravenous route resulted in significant increase in chorionic gonadotropin levels within 30–60 min and the extent of stimulation seemed to depend on the state of pregnancy. For in vitro studies, explants or cells prepared from first trimester human placenta has been used. The functional integrity of these cells has been established by demonstrating the binding of [125I]- labelled human chorionic gonadotropin antibody to the cells as well as the synthesis of [3H]- labelled human chorionic gonadotropin. In vitro studies using the cells revealed that addition of lutropin-releasing hormone caused a significant increase in chorionic gonadotropin and estradiol 17 β secreted into the medium. Thus both in vivo and in vitro results suggest that lutropin-releasing hormone could be one of the factors involved in regulation of chorionic gonadotropin secretion in primates.en_US
dc.identifier.citationRao A Jagannadha, Mathialagan N, Kotagi S G, Moudgal N R. Studies on regulation of chorionic gonadotropin secretion in primates. Journal of Biosciences. 1984 July; 6(suppl_2): s97-s106.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/160459
dc.language.isoenen_US
dc.source.urihttps://www.ias.ac.in/jarch/jbiosci/6/97-106.pdfen_US
dc.subjectChorionic gonadotropinen_US
dc.subjectplacentaen_US
dc.subjectlutropin-releasing hormoneen_US
dc.subjectregulationen_US
dc.subjectprimatesen_US
dc.titleStudies on regulation of chorionic gonadotropin secretion in primates.en_US
dc.typeArticleen_US
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