Studies on regulation of chorionic gonadotropin secretion in primates.
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Date
1984-07
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Abstract
The regulation of secretion of chorionic gonadotropin in primates has been studied
using both in vivo and in vitro models. In vivo studies using the pregnant bonnet monkey
revealed that at the doses tested, the administration of progesterone or estradiol 17β in
combination or alone did not result in any appreciable change in the duration or magnitude of
serum chorionic gonadotropin levels. However, administration of lutropin-releasing hormone
by intravenous route resulted in significant increase in chorionic gonadotropin levels within
30–60 min and the extent of stimulation seemed to depend on the state of pregnancy. For in
vitro studies, explants or cells prepared from first trimester human placenta has been used. The
functional integrity of these cells has been established by demonstrating the binding of [125I]-
labelled human chorionic gonadotropin antibody to the cells as well as the synthesis of [3H]-
labelled human chorionic gonadotropin. In vitro studies using the cells revealed that addition
of lutropin-releasing hormone caused a significant increase in chorionic gonadotropin and
estradiol 17 β secreted into the medium. Thus both in vivo and in vitro results suggest that
lutropin-releasing hormone could be one of the factors involved in regulation of chorionic
gonadotropin secretion in primates.
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Keywords
Chorionic gonadotropin, placenta, lutropin-releasing hormone, regulation, primates
Citation
Rao A Jagannadha, Mathialagan N, Kotagi S G, Moudgal N R. Studies on regulation of chorionic gonadotropin secretion in primates. Journal of Biosciences. 1984 July; 6(suppl_2): s97-s106.