Alterations in brain tumor DNA detected by a fingerprinting probe.

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dc.contributor.authorJoshi, A Ren_US
dc.contributor.authorSinha, Sen_US
dc.contributor.authorDil-Afroz,en_US
dc.contributor.authorSulaiman, I Men_US
dc.contributor.authorBanerji, A Ken_US
dc.contributor.authorHasnain, S Een_US
dc.date.accessioned1996-12-01en_US
dc.date.accessioned2009-05-27T09:11:58Z
dc.date.available1996-12-01en_US
dc.date.available2009-05-27T09:11:58Z
dc.date.issued1996-12-01en_US
dc.description.abstractWe used a novel DNA fingerprinting probe O-chi-1 (ref. 1) to detect differences in the hybridization pattern of brain tumor DNA and paired normal tissue of a given individual. Representatives of meningiomas (two), glioblastoma multeforme (three) and astrocytoma (one) were studied. Alterations, which included amplification as well as the loss of a normal band in tumor DNA, were observed in four of the six tumours. While the increased intensity of a band can be taken to imply increased copy number, the disappearance of bands could either be due to loss of DNA sequence or rearrangement resulting in different sized bands.en_US
dc.description.affiliationDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationJoshi AR, Sinha S, Dil-Afroz , Sulaiman IM, Banerji AK, Hasnain SE. Alterations in brain tumor DNA detected by a fingerprinting probe. Indian Journal of Biochemistry & Biophysics. 1996 Dec; 33(6): 455-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26769
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAstrocytoma --geneticsen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshBrain Neoplasms --geneticsen_US
dc.subject.meshDNA Fingerprinting --methodsen_US
dc.subject.meshDNA Probesen_US
dc.subject.meshDNA, Neoplasm --chemistryen_US
dc.subject.meshDeoxyribonucleases, Type II Site-Specific --metabolismen_US
dc.subject.meshElectrophoresis, Agar Gelen_US
dc.subject.meshGlioblastoma --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMeningioma --geneticsen_US
dc.titleAlterations in brain tumor DNA detected by a fingerprinting probe.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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