The general skeletal features of Multicentric Carpotarsal Osteolysis:what the radiologist needs to know

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dc.contributor.authorAlbahkali, Sen_US
dc.contributor.authorAlsaiady, Men_US
dc.date.accessioned2024-09-24T08:09:51Z
dc.date.available2024-09-24T08:09:51Z
dc.date.issued2023-12
dc.description.abstractPurpose of review:Radiographic imaging is the first investigational step in detecting Multicentric carporarsal osteolysis, and the radiologist must be aware then familiar with the radiological features in order both to reach a prompt diagnosis and then to classify the patient’s condition at this important time for considering early management. Here we review the literature on this topic. Recent Findings: Patients with multicentric carpotarsal osteolysis (MCTO) are frequently diagnosed with juvenile idiopathic arthritis (JIA). Initially, their symptoms are arthritic and include pain, swelling and stiffness.Among the many published studies, some are case reports that describe the phenotypical manifestations with a brief discussion of the radiographic findings and subsequently of the genetic analysis which eventually leads to a definitive diagnosis.Some patients develop end- stage renal failure, and a delay in identifying this condition can lead to unfavorable progression of the disease.In addition, we found reports of joint inflammation based on imaging and pain relief with antirheumatics for osteolysis and bone destruction. Various studies discuss the radiological findings, including the disappearance of the carpal and tarsal bones.Others describe the genetic mutations, including MAFB, that are associated with the condition, and its possible management through the use of therapeutic drugs.A very recent description of serial radiographs taken from a young age suggests that dysfunctional bone formation can play a role in the skeletal phenotype of MCTO.Summary:The unique features of clinical presentation, atypical radiological findings, failure to obtain remission with medical treatment and consanguinity, should guide clinicians towards the diagnosis of this condition.We summarize the X-ray findings which are highly specific and can therefore differentiate with confidence between this condition and others. Further performance of gene.en_US
dc.identifier.affiliationsSalha M Albahkali, Resident, Radiology Department, King Saud Medical City, Riyadh, Saudi Arabia.en_US
dc.identifier.affiliationsMoath Alsaiady, Pediatric Radiology Consultant, Radiology Department, King Saud Medical City, Riyadh, Saudi Arabia.en_US
dc.identifier.citationAlbahkali S, Alsaiady M. The general skeletal features of Multicentric Carpotarsal Osteolysis:what the radiologist needs to know. International Journal of Medical Research & Review . 2023 Nov; 11(6): 146-158en_US
dc.identifier.issn2320-8686
dc.identifier.issn2321-127X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231051
dc.languageenen_US
dc.publisherSiddharth Health Research and Social Welfare Societyen_US
dc.relation.issuenumber6en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.17511/ijmrr.2023.i06.03en_US
dc.subjectMulticentric carpo-tarsal osteolysisen_US
dc.subjectSkeletonen_US
dc.subjectMAFBen_US
dc.subjectNephropathyen_US
dc.subjectRadiologist.en_US
dc.titleThe general skeletal features of Multicentric Carpotarsal Osteolysis:what the radiologist needs to knowen_US
dc.typeJournal Articleen_US
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