Comparison of high and low dosage of antitetanus serum in the treatment of neonatal tetanus
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1980-01-01
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Abstract
A study was conducted on 106 cases to compare the high dose (50,000 IU) and low dose (10,000 IU) of anti-tetanus serum (horse antitoxin) in the treatment of neonatal tetanus. The cases were graded into 'Mild group' and 'Severe Group' before being included into the trial. The cases in each group were then subjected to 'high dose' or 'low dose' by randomization. The mortality results of the two dosage regimens were compared by sequential "analysis in the 'Severe Group'. Sequential analysis showed that the mortality produced by the two regimens were not statistically significant. Sequential analysis of mortality could not be carried out on the 'Mild Group' as there was only one untied pair, but it was concluded that the two dosage regimens probably would produce the same effect. The clinical course of the patient judged by (a} disappearance of spasms (b) ability to cry (c) starts taking feeds and (d) duration of stay in hospital in the two treatment regimens were also similar in both the 'mild' and 'severe' groups. The comparability of the patients receiving 'high dose' or 'low dose' regimens in relation to prognostic criteria and contributing factors of cause of death were presented and discussed. 'Rationales underlying the design of the study were discussed by review of the literature.
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Than Nu Shwe. Comparison of high and low dosage of antitetanus serum in the treatment of neonatal tetanus. Burma Medical Journal. 1980; 26(2): 77-84