Identification of immune complex antigens in sera of Indian kala-azar patients.

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dc.contributor.authorSanyal, Ten_US
dc.contributor.authorGhosh, D Ken_US
dc.contributor.authorSarkar, Den_US
dc.date.accessioned2009-05-28T16:36:05Z
dc.date.available2009-05-28T16:36:05Z
dc.date.issued1991-05-01en_US
dc.description.abstractLevel of circulating immune complex (IC) in visceral leishmaniasis is much higher than that in control sera. In immunoblot experiment, treatment of kala-azar IC with patient sera showed at least 6 bands of which the band around 55 kDa region was most prominent. The band at 55 kDa is primarily due to the presence of an antigen recognized by its corresponding antibody present in the patient sera. This was confirmed by using radiolabelled antibody from kala-azar patient serum and antipromastigote serum. The heavy chain of IgG originating from IC is also present in the same region which was detected by its recognition with antihuman IgG. The IC gave a band at 55 kDa region with sea-urchin antitubulin. Kala-azar sera also reacted with purified rat brain tubulin. The present results suggest that a tubulin like protein is present at 55 kDa region along with the heavy chain of IgG.en_US
dc.description.affiliationDepartment of Cell Biology, Indian Institute of Chemical Biology, Calcutta.en_US
dc.identifier.citationSanyal T, Ghosh DK, Sarkar D. Identification of immune complex antigens in sera of Indian kala-azar patients. Indian Journal of Experimental Biology. 1991 May; 29(5): 411-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63437
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAntigen-Antibody Complex --blooden_US
dc.subject.meshAntigens --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshLeishmaniasis, Visceral --immunologyen_US
dc.titleIdentification of immune complex antigens in sera of Indian kala-azar patients.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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