Reworking the treatment of Indian Post kala-azar dermal leishmaniasis: A two-step therapy

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dc.contributor.authorKathuria, Sushrutaen_US
dc.contributor.authorGautam, Yuganshen_US
dc.contributor.authorKhunger, Nitien_US
dc.contributor.authorSharma, Shrutien_US
dc.contributor.authorSingh, Ruchien_US
dc.date.accessioned2025-08-13T09:35:52Z
dc.date.available2025-08-13T09:35:52Z
dc.date.issued2025-06
dc.description.abstractIn the current scenario, treatment of Post kala-azar dermal leishmaniasis (PKDL) is intravenous liposomal amphotericin B or oral miltefosine. Over the years, there has been a gradual decline in the efficacy of miltefosine and a rise in permanent loss of vision. Moreover, in non-endemic states of India, miltefosine is not freely available. In view of this, we attempted a two-step regimen of liposomal amphotericin B and itraconazole to treat two patients of PKDL diagnosed on histopathology as well as PCR. We found this treatment to be highly effective with complete recovery.en_US
dc.identifier.affiliationsDepartment of Dermatology and Venerology, Safdarjung Hospital and V Vardhaman Mahavir Medical College, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venerology, Safdarjung Hospital and V Vardhaman Mahavir Medical College, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology and Venerology, Safdarjung Hospital and V Vardhaman Mahavir Medical College, New Delhi, Indiaen_US
dc.identifier.affiliationsICMR- National Institute of Pathology, New Delhi, Indiaen_US
dc.identifier.affiliationsICMR- National Institute of Pathology, New Delhi, Indiaen_US
dc.identifier.citationKathuria Sushruta, Gautam Yugansh, Khunger Niti, Sharma Shruti, Singh Ruchi. Reworking the treatment of Indian Post kala-azar dermal leishmaniasis: A two-step therapy. Journal of Vector Borne Diseases . 2025 Jun; 62(2): 248-251en_US
dc.identifier.issn0972-9062
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252562
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume62en_US
dc.source.urihttps://doi.org/10.4103/JVBD.JVBD_205_24https://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.subjectpost kala azar dermal leishmaniasisen_US
dc.subjectitraconazoleen_US
dc.subjectamphotericin Ben_US
dc.titleReworking the treatment of Indian Post kala-azar dermal leishmaniasis: A two-step therapyen_US
dc.typeJournal Articleen_US
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