A Study of Adverse Drug Effects in Patients with Obsessive Compulsive Disorder

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dc.contributor.authorH, SNen_US
dc.contributor.authorNischal, Aen_US
dc.contributor.authorNischal, Aen_US
dc.contributor.authorSingh, Aen_US
dc.contributor.authorSachan, AK.en_US
dc.date.accessioned2025-05-12T10:23:18Z
dc.date.available2025-05-12T10:23:18Z
dc.date.issued2024-12
dc.description.abstractAims: To identify and record adverse effects/adverse drug reactions in patients receiving pharmacotherapy for obsessive compulsive disorder (OCD) visiting Psychiatry Out patient department of King George’s Medical University, Lucknow and to assess the causality of adverse drug reactions reported by these patients. Study Design: A prospective observational study. Place and Duration of Study: This study was conducted in the Department of Pharmacology, in collaboration with Department of Psychiatry, King George’s Medical University, Lucknow between February 2023 to January 2024. Methods: Patients receiving pharmacotherapy for Obsessive Compulsive disorder were recruited into the study after satisfying inclusion and exclusion criteria and observed for Adverse drug reaction. Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to rate the severity and type of symptoms of OCD. The UKU Side Effect Rating Scale was used for assessing the side effects of medications prescribed to OCD patients and the causality of the observed adverse effects. Quantitative data summarized as Mean and Chi-Square test used for analysis of Qualitative data. Results: A total of 72 patients were included in the study out of which 37(51.3%) developed adverse drug reactions during the study period. Most of the adverse drug reactions occurred in 18-30 years group (62.1%) with majority in male group(54%). Psychic type adverse drug reactions were commonly observed (54%) with majority reported with fluoxetine (72.9%) and dyspepsia (24.3%) was the most commonly observed adverse drug reaction. On causality assessment, most of the adverse drug reactions belonged to possible type (75.7%). 75.7% adverse drug reactions required symptomatic treatment and remaining 24.3% resolved spontaneously. Conclusion: This study provides a representative profile of the adverse drug reactions which can be expected in obsessive compulsive disorder patients receiving pharmacotherapy. Nearly half of the study participants experienced adverse effects. Regular monitoring of ADRs in psychiatry OPD and educating the patients about ADR can reduce the risk and it may improve the quality of care, reduction in cost of treatment, adherence to drugs and improved outcome.en_US
dc.identifier.affiliationsDepartment of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry, King George’s Medical University, Lucknow, Indiaen_US
dc.identifier.affiliationsDepartment of Psychiatry, King George’s Medical University, Lucknow, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, India.en_US
dc.identifier.citationH SN, Nischal A, Nischal A, Singh A, Sachan AK.. A Study of Adverse Drug Effects in Patients with Obsessive Compulsive Disorder . Journal of Pharmaceutical Research International. 2024 Dec; 36(12): 94-103en_US
dc.identifier.issn2456-9119
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247693
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber12en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jpri/2024/v36i127631en_US
dc.subjectAdverse drug reactionsen_US
dc.subjectfluoxetineen_US
dc.subjectobsessive compulsive disorderen_US
dc.subjectselective serotonin reuptake inhibitorsen_US
dc.subjecttricyclic antidepressantsen_US
dc.subjectY-BOCSen_US
dc.titleA Study of Adverse Drug Effects in Patients with Obsessive Compulsive Disorderen_US
dc.typeJournal Articleen_US
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