An Evaluation of Beta-Lactamase Prevalence and the Increasing Incidence of MBL in Gram-Negative Bacteria.

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dc.contributor.authorJoshi, Aen_US
dc.contributor.authorNirkhiwale, Nen_US
dc.contributor.authorBhasin, Sen_US
dc.contributor.authorTripathi, A.en_US
dc.date.accessioned2025-05-14T09:34:57Z
dc.date.available2025-05-14T09:34:57Z
dc.date.issued2024-12
dc.description.abstractPurpose: ?-lactamase mediated resistance mechanisms in gram-negative bacteria play a pivotal role in spreading antimicrobial resistance. We conducted this study to understand the prevalence of ?-lactamases in Gram-negative bacteria in our region. Methodology: We conducted a cross-sectional study that included 3710 clinical specimens for culture tests from 2021 to 2023 following standard CLSI guidelines. Result: Extended spectrum ?-lactamase resistance was the leading antimicrobial resistance mechanism detected in 53% E. coli isolates, followed by metallo ?-lactamases (14%). Klebsiella pneumoniae was the second most predominant organism isolated, where 28% isolates exhibited metallo ?-lactamase-mediated resistance. Comparative analysis of resistance levels in 2021 and 2022 revealed an increase in the prevalence of MBL resistance by 33% in K. pneumoniae. The prevalence of MBL producing P. aeruginosa increased by 51% from 2021 to 2022. Conclusion: The comparative resistance analysis between 2021 and 2022 highlights the impact of COVID-19 on the expedited rise of antimicrobial resistance.en_US
dc.identifier.affiliationsPh.D. Scholar, Amity University Rajasthan, Jaipuren_US
dc.identifier.affiliationsDirector Clinical Microbiology and Transfusion Medicine, Medicare Hospital & Research Centre, Indoreen_US
dc.identifier.affiliationsProfessor and Head, Department of Biosciences, Maharaja Ranjit Singh College of Professional Sciences, Indoreen_US
dc.identifier.affiliationsAssistant Professor, Amity University Rajasthan, Jaipur.en_US
dc.identifier.citationJoshi A, Nirkhiwale N, Bhasin S, Tripathi A. . An Evaluation of Beta-Lactamase Prevalence and the Increasing Incidence of MBL in Gram-Negative Bacteria.. Online Journal of Health and Allied Sciences. 2024 Dec; 23(92): 1-4en_US
dc.identifier.issn0972-5997
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247870
dc.languageenen_US
dc.publisherLight House Polyclinicen_US
dc.relation.issuenumber92en_US
dc.relation.volume23en_US
dc.source.urihttps://www.ojhas.org/issue92/2024-4-4.pdfen_US
dc.subjectAntimicrobial resistanceen_US
dc.subject?-lactamasesen_US
dc.subjectGram-negative bacteriaen_US
dc.subjectCarbapenem resistanceen_US
dc.subjectESBLen_US
dc.subjectAmpC BL.en_US
dc.titleAn Evaluation of Beta-Lactamase Prevalence and the Increasing Incidence of MBL in Gram-Negative Bacteria.en_US
dc.typeJournal Articleen_US
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