An Evaluation of Beta-Lactamase Prevalence and the Increasing Incidence of MBL in Gram-Negative Bacteria.
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Date
2024-12
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Light House Polyclinic
Abstract
Purpose: ?-lactamase mediated resistance mechanisms in gram-negative bacteria play a pivotal role in spreading antimicrobial resistance. We conducted this study to understand the prevalence of ?-lactamases in Gram-negative bacteria in our region. Methodology: We conducted a cross-sectional study that included 3710 clinical specimens for culture tests from 2021 to 2023 following standard CLSI guidelines. Result: Extended spectrum ?-lactamase resistance was the leading antimicrobial resistance mechanism detected in 53% E. coli isolates, followed by metallo ?-lactamases (14%). Klebsiella pneumoniae was the second most predominant organism isolated, where 28% isolates exhibited metallo ?-lactamase-mediated resistance. Comparative analysis of resistance levels in 2021 and 2022 revealed an increase in the prevalence of MBL resistance by 33% in K. pneumoniae. The prevalence of MBL producing P. aeruginosa increased by 51% from 2021 to 2022. Conclusion: The comparative resistance analysis between 2021 and 2022 highlights the impact of COVID-19 on the expedited rise of antimicrobial resistance.
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Keywords
Antimicrobial resistance, ?-lactamases, Gram-negative bacteria, Carbapenem resistance, ESBL, AmpC BL.
Citation
Joshi A, Nirkhiwale N, Bhasin S, Tripathi A. . An Evaluation of Beta-Lactamase Prevalence and the Increasing Incidence of MBL in Gram-Negative Bacteria.. Online Journal of Health and Allied Sciences. 2024 Dec; 23(92): 1-4