Impact of coronavirus disease pandemic on antimicrobials consumption and antimicrobial resistance during the first and second wave in a tertiary care hospital, in India

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dc.contributor.authorBhardwaj, A.en_US
dc.contributor.authorAgarwal, R.en_US
dc.contributor.authorMangesh, M.en_US
dc.contributor.authorBhardwaj, A.en_US
dc.date.accessioned2024-09-24T06:10:33Z
dc.date.available2024-09-24T06:10:33Z
dc.date.issued2023-12
dc.description.abstractBackground: This study measured the impact of the first and second wave of COVID-19 pandemic (in the year 2020-21) on the antibiotics uses and their effect on gram nehative bacterial species Klebsiella, Enterobacter, Pseudomonas and Acinetobacter. Methods: The number of patient admission month-wise, antibiotic consumption, blood cultures collected, number of positive BCs, and antibiotic resistance were analysed retrospectively for the years 2020, 2021, and 2019 for comparison, in tertiary care hospital (ca. 840 beds). Results: Half of patients admitted in years 2020 and 2021 in our hospital had COVID-19. A significant increase in total antibiotic consumption during the years 2020 (75.53 DDD per 100 admissions) and 2021 (91.71 DDD per 100 admissions) occurred in comparison to the year 2019 (52.5 DDD per 100 admissions). The rate ratio of BCs per 100 admissions increased by 74% in the year 2020, and 118% in the year 2021 in comparison with the rate ratio to the year 2019. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, the rate ratio of BSIs per 100 admissions raised 58.4% for Klebsiella and 239.3% for E. coli, but remain the same for Acinetobacter and Aeruginosa. A sharp increase in the rate of BSIs caused by microorganisms resistant to cephalosporins was also observed in the years 2020 and 2021. Conclusions: present study highlights the impact of the first and second waves of the COVID-19 pandemic on antibiotic consumption and the increasing prevalence hospital-acquired infections and antimicrobial resistance.en_US
dc.identifier.affiliationsUniversity College of Medical Science, GTB Hospital, Dilshad Garden, Delhi, Indiaen_US
dc.identifier.affiliationsNational Institute of Medical Sciences and Research, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsUniversity College of Medical Science, GTB Hospital, Dilshad Garden, Delhi, Indiaen_US
dc.identifier.affiliationsUniversity College of Medical Science, GTB Hospital, Dilshad Garden, Delhi, Indiaen_US
dc.identifier.affiliationsUniversity College of Medical Science, GTB Hospital, Dilshad Garden, Delhi, Indiaen_US
dc.identifier.citationBhardwaj A., Agarwal R., Mangesh M., Bhardwaj A.. Impact of coronavirus disease pandemic on antimicrobials consumption and antimicrobial resistance during the first and second wave in a tertiary care hospital, in India. International Journal of Basic & Clinical Pharmacology. 2023 Nov; 12(6): 828-835en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226591
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20233194en_US
dc.subjectCOVID-19en_US
dc.subjectDefine daily doseen_US
dc.subjectAWaRe classificationen_US
dc.subjectHospital-acquired bloodstream infectionsen_US
dc.subjectAntimicrobial resistanceen_US
dc.titleImpact of coronavirus disease pandemic on antimicrobials consumption and antimicrobial resistance during the first and second wave in a tertiary care hospital, in Indiaen_US
dc.typeJournal Articleen_US
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