Phytochemical and Antioxidant Investigations of Extracts from the Leaves of Macaranga heterophylla (M黮l. Arg.) (Euphorbiaceae), A Medicinal Species used in C魌e d'Ivoire

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dc.contributor.authorN抍ho, Agui� Guy-Rodolpheen_US
dc.contributor.authorN抔aman-Kouassi, Kohu� Christelle Chantalen_US
dc.contributor.authorN抔uessan, Benoit Bangaen_US
dc.contributor.authorSarkodie, Joseph Aduseien_US
dc.contributor.authorAdi-Dako, Ofosuaen_US
dc.contributor.authorMamyrbekova-B閗ro, Janat Akhanovnaen_US
dc.contributor.authorB閗ro, Yves-Alainen_US
dc.date.accessioned2024-09-24T06:22:56Z
dc.date.available2024-09-24T06:22:56Z
dc.date.issued2024-05
dc.description.abstractAims: This work aims to investigate the phytochemical composition and antioxidant potential of the leaves of Macaranga heterophylla.Methodology: For this purpose, phytochemical screening by detection tests and thin layer chromatography (TLC), determination of total phenols content, total flavonoids content and condensed tannins content, and assessment of antioxidant potential by DPPH and reducing power tests were carried out on aqueous crude extracts, ethanolic crude extracts and selective extracts of the leaves of M. heterophylla.Results: The percentage yields obtained with ethanol (70%) (28.90 and 24.70% for the ethanolic decoction and ethanolic macerate respectively) are higher than those obtained with water (24.30 and 21.10% for the aqueous decoction and aqueous macerate respectively). The phytochemical screening highlighted the presence of several phytochemical families such as phenolic compounds (coumarins, flavones, tannins), quinones, sterols and polyterpenes, saponosides, glycosides, cardiotonic glycosides and oligosaccharides. Quantitative analysis of total phenolics, total flavonoids and proanthocyanidols showed that their respective levels in the leaves of M. heterophylla varied depending on the solvent and the extraction technique. Concerning total phenolics, the aqueous decoction and ethanolic macerate gave the best total phenol contents (129.04 � 9.53 and 119.82 � 2.63 mg EAG/g DM respectively); for total flavonoids, the aqueous decoction gave the best content (33.03 � 1.61 mg EQ/g DM), while for condensed tannins, the aqueous macerate gave the best content (0.87 � 0.02 mg ECT/g DM). With regard to DPPH antioxidant activity, the results showed that the ethanolic decoction has more pronounced antioxidant activity than the aqueous decoction, while the aqueous macerate showed better antioxidant activity than the ethanolic macerate. Concerning the reducing power test, the opposite trend was observed.Conclusion: The present study demonstrated that M. heterophylla is a concentrate of secondary metabolites with antioxidant properties, which would explain its use in traditional medicinal practice.en_US
dc.identifier.affiliationsLaboratory of Organic Bio Chemistry and Natural Substances, UFR-SFA / Nangui Abrogoua University, 02 BP 801 Abidjan 02, C魌e d扞voireen_US
dc.identifier.affiliationsLaboratory of Organic Bio Chemistry and Natural Substances, UFR-SFA / Nangui Abrogoua University, 02 BP 801 Abidjan 02, C魌e d扞voireen_US
dc.identifier.affiliationsDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health sciences, University of Ghana, P.O. Box LG 43 Legon, Accra, Ghana, Institute of Traditional and Alternative Medecine, University of Health and Allied Sciences (UHAS), PMB 31, Ho, Volta Region, Ghana and Department of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences (UHAS), PMB 31, Ho, Volta Region, Ghanaen_US
dc.identifier.affiliationsDepartment of Pharmacognosy and Herbal Medicine, School of Pharmacy, College of Health Sciences, University of Ghana, P.O. Box LG 43, Legon, Accra, Ghanaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Microbiology, School of Pharmacy, University of Ghana, P.O. Box LG 43, Legon, Accra, Ghanaen_US
dc.identifier.affiliationsLaboratory of Organic Bio Chemistry and Natural Substances, UFR-SFA / Nangui Abrogoua University, 02 BP 801 Abidjan 02, C魌e d扞voireen_US
dc.identifier.affiliationsLaboratory of Organic Bio Chemistry and Natural Substances, UFR-SFA / Nangui Abrogoua University, 02 BP 801 Abidjan 02, C魌e d扞voireen_US
dc.identifier.citationN抍ho Agui� Guy-Rodolphe, N抔aman-Kouassi Kohu� Christelle Chantal, N抔uessan Benoit Banga, Sarkodie Joseph Adusei, Adi-Dako Ofosua, Mamyrbekova-B閗ro Janat Akhanovna, B閗ro Yves-Alain. Phytochemical and Antioxidant Investigations of Extracts from the Leaves of Macaranga heterophylla (M黮l. Arg.) (Euphorbiaceae), A Medicinal Species used in C魌e d'Ivoire . International Journal of Medical Research & Health Sciences. 2024-May; 33(5): 97-109en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226843
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber5en_US
dc.relation.volume33en_US
dc.source.urihttps://doi.org/ 10.9734/ijbcrr2024/v33i5880en_US
dc.subjectMacaranga heterophyllaen_US
dc.subjectleavesen_US
dc.subjectphytoconstituentsen_US
dc.subjectantioxidant activityen_US
dc.titlePhytochemical and Antioxidant Investigations of Extracts from the Leaves of Macaranga heterophylla (M黮l. Arg.) (Euphorbiaceae), A Medicinal Species used in C魌e d'Ivoireen_US
dc.typeJournal Articleen_US
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