Prion diseases: A challenge to animal health.
Loading...
Date
2011-12
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Prion diseases are known as transmissible spongiform encephalopathies (TSE), a group
of rare, rapidly progressive, and fatal neurologic diseases. The agents responsible for human and
animal prion diseases are abnormal proteins (prion or proteinaceous infectious particle) that can
trigger chain reactions causing normal proteins in the brain to change to the abnormal protein.
These abnormal proteins are resistant to enzymatic breakdown, and they accumulate in the brain,
leading to damage. All have long incubation periods followed by chronic neurological disease and
fatal outcomes, have similar pathology limited to the CNS include convulsions, dementia, ataxia
(balance and coordination dysfunction), and behavioral changes, and are experimentally
transmissible to some other species.
Description
Keywords
Bovine spongiform encephalopathy, Chronic wasting disease, Exotic ungulate encephalopathy, Feline spongiform encephalopathy, Mad cow disease, Prion, Scrapie, Transmissible mink encephalopathy
Citation
Dudhatra G B, Mody S K, Patel H B, Modi C M, Kumar Avinash, Awale M M. Prion diseases: A challenge to animal health. Journal of Applied Pharmaceutical Science. 2011 Dec; 1(10): 215-221.