Flow cytometric analysis of T4:T8 splenic cell during dengue virus infection of mice.

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dc.contributor.authorDhawan, Ren_US
dc.contributor.authorMukerjee, Ren_US
dc.contributor.authorChaturvedi, U Cen_US
dc.contributor.authorKhare, S Den_US
dc.date.accessioned2009-05-28T14:27:56Z
dc.date.available2009-05-28T14:27:56Z
dc.date.issued1995-11-01en_US
dc.description.abstractThe present study was undertaken to investigate the effect of dengue type 2 virus (DV) and DV-induced cytokines (CF and CF2) on T lymphocyte subpopulations of spleen by flow cytometry. Following DV-ic inoculation in mice the percent number of CD4+ and CD8+ lymphocytes in the spleen was reduced, the peak reduction in both was observed on the 6th day post-inoculation (p.i.). Intravenous inoculation of CF or CF2 in mice also decreased the percent number of CD4+ as well as CD8+ T lymphocytes subpopulation in the spleen, the maximum reduction being observed at 1 and 2 hr, respectively. The reduction in T lymphocyte subpopulation by CF and CF2 was found to be dose dependent. Thus, the alterations of T lymphocyte subpopulations during DV infection are mediated via cytokines.en_US
dc.description.affiliationPostgraduate Department of Microbiology, K G Medical College, Lucknow, India.en_US
dc.identifier.citationDhawan R, Mukerjee R, Chaturvedi UC, Khare SD. Flow cytometric analysis of T4:T8 splenic cell during dengue virus infection of mice. Indian Journal of Experimental Biology. 1995 Nov; 33(11): 816-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60743
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCD4-CD8 Ratioen_US
dc.subject.meshCytokines --biosynthesisen_US
dc.subject.meshDengue --immunologyen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshSpleen --immunologyen_US
dc.titleFlow cytometric analysis of T4:T8 splenic cell during dengue virus infection of mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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