Microneedles: An advancement to transdermal drug delivery system approach

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dc.contributor.authorAgrawal, Surendraen_US
dc.contributor.authorGandhi, Suchi N.en_US
dc.contributor.authorGurjar, Pravinaen_US
dc.contributor.authorSaraswathy, Nagendranen_US
dc.date.accessioned2020-10-16T08:56:51Z
dc.date.available2020-10-16T08:56:51Z
dc.date.issued2020-03
dc.description.abstractNovel drug delivery system offers several advantages which could outweigh the benefits of other drug deliverysystems. The transdermal drug delivery system being one of them offers supremacy by by-passing the first passmetabolism which eventually helps in eradication of gastrointestinal irritation. However, the major drawback of thetransdermal drug delivery system is the hindrance created via the stratum corneum. This protective barrier of the skindoes not allow required penetration of the drug via skin into the systemic circulation. Thus, in order to overcome thishurdle, a replacement to this type of novel drug delivery system, namely, “microneedle drug delivery system” helpedto improve various pitfalls of transdermal drug delivery system, such as skin barrier function, restrictions towardusing of specific drugs only, bioavailability, patient compliance, diffusion rate, and plasma concentration level. Amicroneedle drug delivery system, thus, is advancement to transdermal drug delivery system which includes deliveryof drug via microneedle into systemic circulation, thus increasing patient compliance and avoiding problems renderedby transdermal drug delivery system.en_US
dc.identifier.affiliationsShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai 400056, India.en_US
dc.identifier.affiliationsShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai 400056, India.en_US
dc.identifier.affiliationsSharadchandra Pawar College of Pharmacy, Otur, Maharashtra, India.en_US
dc.identifier.affiliationsShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai 400056, India.en_US
dc.identifier.citationAgrawal Surendra, Gandhi Suchi N., Gurjar Pravina, Saraswathy Nagendran. Microneedles: An advancement to transdermal drug delivery system approach. Journal of Applied Pharmaceutical Science. 2020 Mar; 2020 Mar: 149-159en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210719
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber3en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.103019en_US
dc.subjectTransdermal systemen_US
dc.subjectmicroneedleen_US
dc.subjectmicroneedle patentsen_US
dc.subjectmicroneedle applicationsen_US
dc.subjectskin barrier functionen_US
dc.subjectrole of microneedle.en_US
dc.titleMicroneedles: An advancement to transdermal drug delivery system approachen_US
dc.typeJournal Articleen_US
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