Microneedles: An advancement to transdermal drug delivery system approach
Loading...
Date
2020-03
Journal Title
Journal ISSN
Volume Title
Publisher
Open Science Publishers LLP
Abstract
Novel drug delivery system offers several advantages which could outweigh the benefits of other drug deliverysystems. The transdermal drug delivery system being one of them offers supremacy by by-passing the first passmetabolism which eventually helps in eradication of gastrointestinal irritation. However, the major drawback of thetransdermal drug delivery system is the hindrance created via the stratum corneum. This protective barrier of the skindoes not allow required penetration of the drug via skin into the systemic circulation. Thus, in order to overcome thishurdle, a replacement to this type of novel drug delivery system, namely, “microneedle drug delivery system” helpedto improve various pitfalls of transdermal drug delivery system, such as skin barrier function, restrictions towardusing of specific drugs only, bioavailability, patient compliance, diffusion rate, and plasma concentration level. Amicroneedle drug delivery system, thus, is advancement to transdermal drug delivery system which includes deliveryof drug via microneedle into systemic circulation, thus increasing patient compliance and avoiding problems renderedby transdermal drug delivery system.
Description
Keywords
Transdermal system, microneedle, microneedle patents, microneedle applications, skin barrier function, role of microneedle.
Citation
Agrawal Surendra, Gandhi Suchi N., Gurjar Pravina, Saraswathy Nagendran. Microneedles: An advancement to transdermal drug delivery system approach. Journal of Applied Pharmaceutical Science. 2020 Mar; 2020 Mar: 149-159