Formulation and In-Vivo Study of Diltiazem Hydrochloride Tablets Prepared Using Interpolymer Complexes.

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dc.contributor.authorAbd EL – Gawad, Abd EL – Gawad H
dc.contributor.authorRamadan, Esmail M
dc.contributor.authorSoliman, Osama A
dc.contributor.authorYusif, Rehab M
dc.date.accessioned2015-09-05T09:39:42Z
dc.date.available2015-09-05T09:39:42Z
dc.date.issued2012-01
dc.description.abstractAim: To investigate interpolymer complexes (IPCs) formation between carbopol and cationic polymers such as chitosan and Eudragit E for oral controlled drug delivery systems. Methodology: The prepared IPCs were investigated using Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Chitosan-carbopol and Eudragit E-carbopol IPCs loaded with diltiazem hydrochloride (DTZ HCl) with different drug:polymer ratios were also prepared. Diltiazem hydrochloride tablets were prepared using polymers alone, physical mixtures of chitosan or Eudragit E with carbopol and the corresponding drug loaded IPCs. In-vitro release studies were carried out in two dissolution media; 0.1 NHCl of pH 1.2 and phosphate buffer of pH 7.4. Results: The dissolution rate of DTZ HCl from the prepared tablets were found to be dependant on the interaction between chitosan or Eudragit E with carbopol in the physical mixture, drug:polymer ratio and pH of the dissolution medium. Tablets prepared using chitosan – carbopol IPC, Eudragit E – carbopol IPC, and Eudragit E – carbopol physical mixture of drug:polymer ratio 1:5 were selected for the in-vivo study using rabbits. The results showed a lower peak plasma concentration and marked prolonged release effect of tablets containing Eudragit E – carbopol IPC and the corresponding physical mixture compared to that of commercial Altiazem tablets. Conclusion: Tablets containing Eudragit E – carbopol or chitosan – carbopol physical mixtures showed prolonged drug release compared to that containing the corresponding IPCs, Furthermore, Eudragit E- carbopol matrix tablets showed slower drug release than that of chitosan – carbopolen_US
dc.identifier.citationAbd EL – Gawad Abd EL – Gawad H, Ramadan Esmail M, Soliman Osama A, Yusif Rehab M. Formulation and In-Vivo Study of Diltiazem Hydrochloride Tablets Prepared Using Interpolymer Complexes. British Journal of Pharmaceutical Research. 2012 Jan-Mar; 2(1): 17-40.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163157
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/361en_US
dc.subjectChitosanen_US
dc.subjectEudragit Een_US
dc.subjectCarbopolen_US
dc.subjectdiltiazem hydrochlorideen_US
dc.subjectinterpolymer complexen_US
dc.subjecttabletsen_US
dc.titleFormulation and In-Vivo Study of Diltiazem Hydrochloride Tablets Prepared Using Interpolymer Complexes.en_US
dc.typeArticleen_US
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