Synergistic activity of ofloxacin and ornidazole on biomedical fabrics against nosocomial pathogens.

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dc.contributor.authorRajendran, R
dc.contributor.authorElayarajah, B
dc.contributor.authorVenkatrajah, B
dc.contributor.authorBalakumar, C
dc.contributor.authorAsa, Sudhakar
dc.contributor.authorJaniga, P K
dc.contributor.authorDevika, S
dc.date.accessioned2015-08-11T07:22:26Z
dc.date.available2015-08-11T07:22:26Z
dc.date.issued2011-04
dc.description.abstractNosocomial infections in the hospitals disseminated from the cotton fabrics of health care professionals and patients leads to severe complications like respiratory, gastrointestinal and urinary tract infections. Since the hospital based textile materials like nylon and polyester has good surface properties, it can harbour large number of microorganisms. Hence in this study, two different antibacterial drugs showing synergistic properties were attached to different fabricsusing tocopherol acetate as a cross-linker with the aim that, treated fabric could act as barriers against transmission of challenge organisms. Inorder to decrease the drug resistant property of the nosocomial pathogens, a fluoroquinolone and a nitroimidazole compounds were mixed at suitable composition based on their synergistic behaviour. Both the compounds were modified to act as reactive dyes and were covalently bonded to the surface of nylon and polyester in order to impart antibacterial properties. The assay used for measuring antibacterial properties was based on the AATCC Test Method-100. The treated fabric was also subjected to multiple washings to determine its durability based on the AATCC Test Method-124. To determine the mode of action of these drugs, DNA of the drug exposed and unexposed challenge organisms were extracted and analysed by agarose gel electrophoresis. The difference in the number of viable bacteria after ‘0’ contact time and 18 hours contact time with treated fabrics were statistically calculated with P<0.05 considered significant.en_US
dc.identifier.citationRajendran R, Elayarajah B, Venkatrajah B, Balakumar C, Asa Sudhakar, Janiga.P K, Devika S. Synergistic activity of ofloxacin and ornidazole on biomedical fabrics against nosocomial pathogens. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Apr-June; 2(2): 434-447.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/161771
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?fid=330en_US
dc.subjectReactive dye methoden_US
dc.subjectAATCC-100en_US
dc.subjectAATCC-124en_US
dc.subjectbeta-cyclodextrinen_US
dc.subjectagarose gel electrophoresisen_US
dc.titleSynergistic activity of ofloxacin and ornidazole on biomedical fabrics against nosocomial pathogens.en_US
dc.typeArticleen_US
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