Precocious desynapsis of XY-bivalent in mouse germinal cells: influence of mitomycin C on tumour-bearing and normal mice.

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dc.contributor.authorDey, Den_US
dc.contributor.authorPradhan, Men_US
dc.contributor.authorDas, S Ben_US
dc.contributor.authorChakrabarti, Sen_US
dc.date.accessioned2009-05-28T10:43:44Z
dc.date.available2009-05-28T10:43:44Z
dc.date.issued1989-09-01en_US
dc.description.abstractA comparative study on the cytotoxic potential of anticancer-antibiotic mitomycin C has been made on tumour-bearing and normal mice considering precocious desynapsis of sex bivalent as parameter. The study indicates a strikingly differential effect of the drug on the phenomenon in two different types of mice. The administration of mitomycin C at therapeutic dose although enhances the frequency of precocious desynapsis of XY-bivalent in non-tumour (normal) mice to a significant extent (compared to control), the same drug at the same dose fails to produce a similar effect on tumour-bearing specimens. Discussions have been made on: (i) the probable cause for this differential effect, (ii) the mechanism of mitomycin action on precocious desynapsis of sex bivalent and, (iii) the possible significance of the findings in relation to cancer chemotherapy.en_US
dc.identifier.citationDey D, Pradhan M, Das SB, Chakrabarti S. Precocious desynapsis of XY-bivalent in mouse germinal cells: influence of mitomycin C on tumour-bearing and normal mice. Indian Journal of Experimental Biology. 1989 Sep; 27(9): 757-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55714
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Division --drug effectsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMitomycinen_US
dc.subject.meshMitomycins --pharmacologyen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshX Chromosome --drug effectsen_US
dc.subject.meshY Chromosome --drug effectsen_US
dc.titlePrecocious desynapsis of XY-bivalent in mouse germinal cells: influence of mitomycin C on tumour-bearing and normal mice.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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