Effect Of Different Formulation Variables On Release Characteristics Of Gastro-Floating Microspheres Of Ethyl Cellulose/Carbopol 934p Encapsulating Sorafenib

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dc.contributor.authorAhmed, M. M.en_US
dc.date.accessioned2020-09-24T08:01:19Z
dc.date.available2020-09-24T08:01:19Z
dc.date.issued2019-10
dc.description.abstractObjective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability.  Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P were used as the encapsulating carriers. The effects of formulation parameters like, solvent volume ratio, and drug to polymer ratio (D: P ratio), encapsulation efficiency percentage EE%, floating percentage, and release of SFN after 12 h (Rel12) were investigated and analyzed using a (32) full factorial design. Results: The floating percentage of the microspheres was found to be 76.5%. The in vitro drug release from these hollow microspheres followed the Higuchi model equation. The in vivo results showed that approximately 1.96-fold improvement in the relative bioavailability of the microspheres compared with that of the commercial tablet.  Conclusion: The results demonstrate that the hollow microspheres with good gastro-floating ability are a promising delivery system to enhance SFN bioavailability.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, Egypten_US
dc.identifier.citationAhmed M. M.. Effect Of Different Formulation Variables On Release Characteristics Of Gastro-Floating Microspheres Of Ethyl Cellulose/Carbopol 934p Encapsulating Sorafenib. International Journal of Pharmacy and Pharmaceutical Sciences. 2019 Oct; 11(10): 64-70en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205964
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber10en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2019v11i10.34290en_US
dc.subjectSorafeniben_US
dc.subjectGastro-floatingen_US
dc.subjectMicrospheresen_US
dc.subjectEthyl celluloseen_US
dc.subjectCarbopol 934Pen_US
dc.subjectFactorial designen_US
dc.titleEffect Of Different Formulation Variables On Release Characteristics Of Gastro-Floating Microspheres Of Ethyl Cellulose/Carbopol 934p Encapsulating Sorafeniben_US
dc.typeJournal Articleen_US
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