Ofloxacin and Nitrofurantoin sensitivity pattern In Patients of Urinary Tract Infection (UTI) at a tertiary care teaching hospital
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Date
2015-07
Journal Title
Journal ISSN
Volume Title
Publisher
Ibn Sina Academy of Medieval Medicine & Sciences
Abstract
Introduction: UTIs are the second most common bacterial infection in present population. Women are more prone to UTI than Male. Uropathogenic Escherichia coli is responsible for >80% of community acquired UTIs.
Aims: The present study was carried out to compare sensitivity / Resistance between Ofloxacin and Nitrofurantoin in UTI patients.
Methods: This was a prospective, cross-sectional, observatory study conducted on patients (n = 200) suffering from Urinary Tract Infection from March 2014 to February 2015 at the Department of Microbiology and Department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre (TMMC & RC), at a tertiary care teaching hospital, in Moradabad, Uttar Pradesh, India.
Results: UTI was much more common in females (61%, n=122) than in males (39%, n=78). The most common organism isolated was E. coli, 47%(n=94), followed by Klebsiella 34.5%(n=69), staphylococcus 7.5%(n=15), Proteus, pseudomonas 4%(n=8) and enterococcus 3%(n=6). E. coli was highly sensitive to the Ofloxacin 18% (n=36).
Conclusion: Sensitivity pattern of the antimicrobial was found to be more in Nitrofurantoin (57%) was found to be more sensitive than Ofloxacin (40.5%) for the treatment of UTI.
Description
Keywords
Nitrofurantoin, Ofloxacin, Antimicrobial Agents, Sensitivity
Citation
Devmurari Dharmesh, Kamal Chand Miyaan, Singh Shambhu Nath, Kumar Amit. Ofloxacin and Nitrofurantoin sensitivity pattern In Patients of Urinary Tract Infection (UTI) at a tertiary care teaching hospital. International Archives of BioMedical and Clinical Research. 2015 Jul-Sep; 1(1): 17-22