Effect of five-membered heterocycles against Leishmania donovani infection.

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dc.contributor.authorBhatnagar, Sen_US
dc.contributor.authorNigam, Ven_US
dc.contributor.authorGuru, P Yen_US
dc.contributor.authorKatiyar, J Cen_US
dc.contributor.authorMukherjee, Aen_US
dc.contributor.authorGupta, R Cen_US
dc.contributor.authorBatra, Sen_US
dc.contributor.authorSeth, Men_US
dc.contributor.authorBhaduri, A Pen_US
dc.date.accessioned2009-05-28T16:13:24Z
dc.date.available2009-05-28T16:13:24Z
dc.date.issued1992-07-01en_US
dc.description.abstractImpact of change of heteroatom in pentavalent heterocycles, viz., pyrroles, isoxazoles, imidazoles and crotonates on the profile of antileishmanial activity against amastigotes of L. donovani using in vivo test system and macrophage-amastigote culture system has been studied. Sixty-three compounds were tested. Nine imidazoles showed marginal activity in vivo, whereas 3 out of 10 compounds of isoxazolone series and 2 out of 4 substituted aminocrotonates exhibited antileishmanial activity. Of the 30 substituted pyrroles, except 8 all showed antileishmanial activity in vivo on day 7 post treatment.en_US
dc.description.affiliationDivision of Parasitology, Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.citationBhatnagar S, Nigam V, Guru PY, Katiyar JC, Mukherjee A, Gupta RC, Batra S, Seth M, Bhaduri AP. Effect of five-membered heterocycles against Leishmania donovani infection. Indian Journal of Experimental Biology. 1992 Jul; 30(7): 619-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62962
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshHeterocyclic Compounds --therapeutic useen_US
dc.subject.meshLeishmaniasis, Visceral --drug therapyen_US
dc.subject.meshMaleen_US
dc.titleEffect of five-membered heterocycles against Leishmania donovani infection.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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