Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit.

Simple item page
dc.contributor.authorKuriki, Kiyonorien_US
dc.contributor.authorHamajima, Nobuyukien_US
dc.contributor.authorChiba, Hitochien_US
dc.contributor.authorKanemitsu, Yukihideen_US
dc.contributor.authorHirai, Takashien_US
dc.contributor.authorKato, Tomoyukien_US
dc.contributor.authorSaito, Toshikoen_US
dc.contributor.authorMatsuo, Keitaroen_US
dc.contributor.authorKoike, Koichien_US
dc.contributor.authorTokudome, Shinkanen_US
dc.contributor.authorTajima, Kazuoen_US
dc.date.accessioned2009-05-27T17:34:56Z
dc.date.available2009-05-27T17:34:56Z
dc.date.issued2005-01-23en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractHigh consumption of white meat (or saturated fatty acids) and alcohol has been demonstrated to have a tendency to increase the risk of colorectal cancer, according to the level of malondialdehyde-deoxyguanosine adducts derived from lipid per-oxidation in the colorectal mucosa. CD36 plays important roles as a long-chain fatty acid translocase and oxidized low-density lipoprotein (LDL) scavenger, while alcohol is metabolized by aldehyde dehydrogenase 2 (ALDH2) and decreases transiently metabolism of dietary fat and serum lipids. To examine associations between the risk of colorectal cancer and the CD36 gene A52C polymorphism according to the ALDH2 gene Glu487Lys polymorphism and drinking habit, a hospital-based case-control study was conducted with 128 colorectal cancer cases and 238 cancer-free controls. Odds ratios (ORs) for the C/C genotype relative to the A/A genotype were 1.70 [95% confidence interval (CI), 0.76-4.11] and 4.24 (95% CI, 1.42-22.66) for men and women, respectively, with the low-activity (Glu/Lys + Lys/Lys) ALDH2 genotype. The high-activity (Glu/Glu) genotype for men and women had no associations. On the other hand, the OR for the C/C genotype with high frequency of drinking habit relative to the A/A genotype with low frequency of drinking habit among men was 3.63 (95% CI, 1.29-13.15). The number of women with a high frequency drinking habit was too small for any corresponding analyses. Our findings suggest a significant interaction between alcohol consumption and the CD36 gene A52C polymorphism related to the metabolism of long-chain fatty acids and oxidized LDL in the etiology of colorectal cancer.en_US
dc.description.affiliationDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681 Japan. kkuriki@aichi-cc.jpen_US
dc.identifier.citationKuriki K, Hamajima N, Chiba H, Kanemitsu Y, Hirai T, Kato T, Saito T, Matsuo K, Koike K, Tokudome S, Tajima K. Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit. Asian Pacific Journal of Cancer Prevention. 2005 Jan-Mar; 6(1): 62-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37451
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlcohol Drinking --adverse effectsen_US
dc.subject.meshAldehyde Dehydrogenase --geneticsen_US
dc.subject.meshAntigens, CD36 --geneticsen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshColorectal Neoplasms --enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition to Disease --epidemiologyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshJapan --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshRisk Factorsen_US
dc.titleRelation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Asian Pacific Journal of Cancer Prevention