Assessment of efficacy of promethazine on seizure activity and its interactions with antiepileptic drugs lorazepam and sodium valproate in rats

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dc.contributor.authorShinde, Vinoden_US
dc.contributor.authorWarudkar, Sandeshen_US
dc.date.accessioned2020-04-23T08:00:06Z
dc.date.available2020-04-23T08:00:06Z
dc.date.issued2020-01
dc.description.abstractBackground: Presently available antiepileptic drugs are effective in controlling seizures in more than half of patients of all epilepsy but use is often limited by adverse effects. H1 receptor antagonists, have a controversial status in patients of epilepsy. Both pro and antiepileptic effect has been documented in various animal studies. Hence, this study was designed to see the effect of promethazine, an H1 antihistaminic drug and its interactions with antiepileptic drugs lorazepam and sodium valproate in rats.Methods: The effect of promethazine (10 mg/kg) and its interactions with antiepileptic drugs lorazepam and sodium valproate was assessed by using maximal electroshock seizures (MES) and chemoshock pentylenetetrazol (PTZ) method.Results: Promethazine along with lorazepam and sodium valproate in subtherapeutic doses exerted significant protection against MES induced seizures whereas no such protection was observed with PTZ method rather the seizure threshold was reduced.Conclusions: Subtherapeutic doses of promethazine alone and in combination with lorazepam and sodium valproate showed protection against seizures in MES method. However, proconvulsant effect was seen with PTZ method. This shows dual behavior of promethazine on MES and PTZ induced seizures.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Smt. Kashibai Navale Medical College & General Hospital, Narhe, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsMedical Services, Zydus Research Centre, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.citationShinde Vinod, Warudkar Sandesh. Assessment of efficacy of promethazine on seizure activity and its interactions with antiepileptic drugs lorazepam and sodium valproate in rats. International Journal of Basic & Clinical Pharmacology. 2020 Jan; 9(1): 42-47en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200512
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20195590en_US
dc.subjectLorazepamen_US
dc.subjectMaximal electroshock seizuresen_US
dc.subjectPentylenetetrazolen_US
dc.subjectSodium valproateen_US
dc.subjectPromethazineen_US
dc.titleAssessment of efficacy of promethazine on seizure activity and its interactions with antiepileptic drugs lorazepam and sodium valproate in ratsen_US
dc.typeJournal Articleen_US
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