The antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice

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dc.contributor.authorKamdi, Amit S.en_US
dc.contributor.authorKokane, Sarika D.en_US
dc.contributor.authorBohra, Pankaj N.en_US
dc.contributor.authorKalambe, Suvarna M.en_US
dc.date.accessioned2020-04-23T07:52:58Z
dc.date.available2020-04-23T07:52:58Z
dc.date.issued2018-12
dc.description.abstractBackground: Schizophrenia is one of the most distressing central nervous system (CNS) disorders. It is described by positive, negative and cognitive symptoms. These symptoms can be controlled by the antipsychotic medicines. The numerous antipsychotic medications used today are not lacking the adverse drug reactions. The Withania coagulans a susceptible species, is not explored much for its CNS effects except in late seventies. Therefore, it was thought worthwhile to investigate anti-psychotic activities of alcoholic extract of Withania coagulans fruits. The objective of the present study was to assess the antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Cook’s Pole Climb Apparatus for conditioned avoidance response (CAR)Methods: Cook’s Pole Climb Apparatus for conditioned avoidance response was used for assessing the antipsychotic activity of the alcoholic extract of 200mg/kg, 500mg/kg and 1000mg/kg doses of Withania coagulans fruits.Results: There was statistically (p-value >0.05) no significant association between any of the 200mg/kg, 500mg/kg and 1000mg/kg doses of the alcoholic extracts of Withania coagulans fruits with antipsychotic activity in Swiss albino mice.Conclusions: Withania coagulans fruits alcoholic extract did not demonstrate antipsychotic activity in Swiss albino mice under standard conditions.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Government Medical College, Chandrapur, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Government Medical College, Chandrapur, Maharashtra, Indiaen_US
dc.identifier.affiliationsSNEH Foundation, Chinchwad, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsSanjeevani Multipurpose Society, Mul, Chandrapur, Maharashtra, Indiaen_US
dc.identifier.citationKamdi Amit S., Kokane Sarika D., Bohra Pankaj N., Kalambe Suvarna M.. The antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice. International Journal of Basic & Clinical Pharmacology. 2018 Dec; 7(12): 2389-2392en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199940
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20184852en_US
dc.subjectAntipsychoticen_US
dc.subjectAlcoholic extracten_US
dc.subjectConditioned avoidance response (CAR)en_US
dc.subjectFruitsen_US
dc.subjectSwiss albino miceen_US
dc.subjectWithania coagulansen_US
dc.titleThe antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino miceen_US
dc.typeJournal Articleen_US
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