Tumor Necrosis Factor-alpha (-308 G/A) is a Predictor for Development of Gestational Diabetes Mellitus in Saudi Pregnant Women

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dc.contributor.authorQusti, Safaa Y.en_US
dc.contributor.authorLinjawi, Sabahen_US
dc.contributor.authorBakhashab, Sherinen_US
dc.contributor.authorAlghamdi, Aljoharaen_US
dc.contributor.authorBalgoon, Mahaen_US
dc.contributor.authorAlotaibi, Najat A.en_US
dc.contributor.authorQusty, Naeemen_US
dc.date.accessioned2020-09-24T07:28:27Z
dc.date.available2020-09-24T07:28:27Z
dc.date.issued2019-01
dc.description.abstractInflammation may play a role in the pathogenesis of gestational diabetes mellitus (GDM) and also, it is one of the mostpopular pregnancy complications. The goal of the research was to study the association exists among common many formsin the stimulate area (-308G/A) of the TNF-alpha gene and increased danger for become better of GDM in Saudi pregnantwomen population.GDM and healthy subjects were genotyped with PCR- RFLP technique. No association was noticedamong the TNF-α -308 G/A in different and sensitivity to GDM disease in our Saudi cohort. There was a secondarycombination among TNF-α –308 G/A polymorphism in GDM (vs. normal control) (p = 0.605), which its triviality may becaused to survivor agent. The frequency of the -308 A allele (5) and genotype classification was in Hardy-Weinbergequilibrium (GG, n=54; GA, n=41; AA, n=5).The G-308A various, detected by PCR amplification and Nco-1 digestion,determines the lowest of a restriction site finding in a single band of 107 bp (the (A) allele). The (A) allele frequencies of the-308 (G/A) TNFα polymorphism were 26% in the GDM group and 29% in the depend subjects, with no significant differenceamong the two groups may be due to considerable variance in allele frequencies of the polymorphism by BMI quartiles (≥25kg/m2, for each quartile n=86) with -308G allele transporters had contains a higher BMI than A allele transporters(P=0.000**). Furthermore, considerable was found positively correlated with BMI, age, and children number.CONCLUSION: It could concluded that theTNF-α-308 G>A genotype frequency comparison among patients and controlwas not statistically significant in the Saudi women and also, the SNP in situation -308 (G/A) for the human. TNF- gene is adependent danger agent or a predictor for GDM.en_US
dc.identifier.affiliationsFaculty of Public Health, University of Indonesia, Depok, Indonesia.en_US
dc.identifier.affiliationsFaculty of Public Health, University of Indonesia, Depok, Indonesia.en_US
dc.identifier.affiliationsCenter for Health Research, University of Indonesia, Depok, Indonesia.en_US
dc.identifier.affiliationsDepartment of Public Health, Faculty of Health Sciences, Syarif Hidayatullah State Islamic University (UIN),Jakarta, Indonesia.en_US
dc.identifier.citationQusti Safaa Y., Linjawi Sabah, Bakhashab Sherin, Alghamdi Aljohara, Balgoon Maha, Alotaibi Najat A., Qusty Naeem. Tumor Necrosis Factor-alpha (-308 G/A) is a Predictor for Development of Gestational Diabetes Mellitus in Saudi Pregnant Women. International Journal of Medical Research Professionals. 2019 Jan; 8(1): 213-223en_US
dc.identifier.issn2277-3657
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203613
dc.languageenen_US
dc.publisherInternational Journal of Pharmaceutical Research and Allied Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume8en_US
dc.source.urihttps://ijpras.com/storage/models/article/pUGSn3SBgMHayuZMOojk9jI27mC5YFxsJVsf8d8LaKnBG8B0Y8pLIssD3JZy/tumor-necrosis-factor-alpha-308-ga-is-a-predictor-for-development-of-gestational-diabetes-mellitus.pdfen_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.subject-308TNF-α promoteren_US
dc.subjectpolymorphismen_US
dc.subjectSaudi womenen_US
dc.titleTumor Necrosis Factor-alpha (-308 G/A) is a Predictor for Development of Gestational Diabetes Mellitus in Saudi Pregnant Womenen_US
dc.typeJournal Articleen_US
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