Evaluation of the Association between Ischemia Modified Albumin (IMA), Glycemic and Lipid Status in Diabetic Nephropathy

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dc.contributor.authorAfzal, Ahmaden_US
dc.contributor.authorManjrekar, Poornimaen_US
dc.contributor.authorAgarwal, Ashishen_US
dc.contributor.authorYadav, Charuen_US
dc.contributor.authorNadia, Az Zahraen_US
dc.date.accessioned2020-05-05T07:04:25Z
dc.date.available2020-05-05T07:04:25Z
dc.date.issued2019-9
dc.description.abstractIntroduction:Hyperglycemia induced oxidative stress in Type 2 Diabetes Mellitus modifyvarious biomolecules to cause Diabetic Nephropathy (DN). IMA (Ischemia-Modified Albumin) is one such oxidative stress marker already examined in various clinical events but have not yet been evaluated in different stages of DN. Aim:To estimate and assess the relationship of IMA with glycemic status and lipid parameters in all stages of DN. Study Design: Cross-sectional study.Place and Duration of Study: Study was conducted at Department of Biochemistry,Kasturba Medical College Hospitals, Mangaluru conducted between 2014 and 2015 Materials andMethods:There were 60 type 2 diabeticcases and 30 healthy controls. Diabetic cases were further categorized into three equal groups on the basis of UACR (urine albumin-creatinine ratio), DN stage I having UACR less than 30 mg/g, DN stage II having UACR 30 to 300 mg/g, and DN stage III havingUACR ≥ 300 mg/g of creatinine. Using enzyme-linked immunosorbent assay serum IMA level was estimated whereas automated analyzers was used for serum creatinine, HbA1c, urine albumin and urine creatinine analysis.Results:Lowest level of IMA (109 ng/mL) measured in DN stage I, which was significantly different from those in DN stage II (154 ng/mL) and DN stage III (178 ng/mL). The significant positive correlation between IMA and fasting blood glucose, glycated hemoglobin were present in stage II and stage III DN. In this study significant positive correlation of serum IMA to serum total cholesterol, low density lipoprotein cholesterol and negative correlation with high density lipoprotein were revealed in all stage of DN. Conclusion:Current study postulates that early evaluation of serum IMA in diabetic patients with deranged lipid profile will provide an index of nephropathy development. This will help in prognosis and controlling complication in diabetes mellitus.en_US
dc.identifier.affiliationsDepartment of Biochemistry, GS Medical College and Hospital, Pilkhuwa, U.P, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Kasturba Medical College, Mangaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Lady Harding Medical College, New Delhi, India.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Nalanda Medical College, Patna, Bihar, Indiaen_US
dc.identifier.citationAfzal Ahmad, Manjrekar Poornima, Agarwal Ashish, Yadav Charu, Nadia Az Zahra. Evaluation of the Association between Ischemia Modified Albumin (IMA), Glycemic and Lipid Status in Diabetic Nephropathy . International Journal of Biochemistry Research & Review. 2019 Sep; 27(2): 1-9en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200723
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume27en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2019/v27i230117en_US
dc.subjectDiabetic nephropathyen_US
dc.subjectdyslipidemiaen_US
dc.subjectischemia-modified albuminen_US
dc.subjectoxidative stressen_US
dc.subjecturine albumin creatinine ratioen_US
dc.titleEvaluation of the Association between Ischemia Modified Albumin (IMA), Glycemic and Lipid Status in Diabetic Nephropathyen_US
dc.typeJournal Articleen_US
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