Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.

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dc.contributor.authorHiwale, A Ren_US
dc.contributor.authorDhuley, J Nen_US
dc.contributor.authorNaik, S Ren_US
dc.date.accessioned2009-05-28T13:51:28Z
dc.date.available2009-05-28T13:51:28Z
dc.date.issued2002-03-15en_US
dc.description.abstractCo-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of piperine on microsomal metabolising enzymes or enzymes system.en_US
dc.description.affiliationResearch and Development Division of Hindustan Antibiotics Limited, Pimperi, Pune 411 018, India.en_US
dc.identifier.citationHiwale AR, Dhuley JN, Naik SR. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian Journal of Experimental Biology. 2002 Mar; 40(3): 277-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59955
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAlkaloidsen_US
dc.subject.meshAmoxicillin --administration & dosageen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Bacterial Agents --administration & dosageen_US
dc.subject.meshBenzodioxolesen_US
dc.subject.meshBiological Availabilityen_US
dc.subject.meshCefadroxil --administration & dosageen_US
dc.subject.meshCefotaxime --administration & dosageen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPiperidines --administration & dosageen_US
dc.subject.meshPolyunsaturated Alkamidesen_US
dc.subject.meshRatsen_US
dc.titleEffect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.en_US
dc.typeJournal Articleen_US
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