Hormonal status and distribution of the ABO system phenotypic groups in menopausal and postmenopausal women with breast tumors

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dc.contributor.authorKoridze, Marinaen_US
dc.contributor.authorBaratashvili, Daviten_US
dc.contributor.authorKhukhunaishvili, Rusudanen_US
dc.contributor.authorNakashidze, Irinaen_US
dc.contributor.authorPetrovic, Ninaen_US
dc.contributor.authorNagervadze, Marinaen_US
dc.contributor.authorZosidze, Natoen_US
dc.contributor.authorTskvitinidze, Sophikoen_US
dc.contributor.authorKotrikadze, Nanulien_US
dc.contributor.authorAhmad, Sarfrazen_US
dc.date.accessioned2020-01-02T06:32:12Z
dc.date.available2020-01-02T06:32:12Z
dc.date.issued2018-02
dc.description.abstractBreast cancer is one of the most frequent neoplastic diseases within the female population worldwide. Hormonal imbalance and the ABO system group antigens are among the numerous risk-factors which provoke the development of breast benign and malignant tumors. Here, we have investigated the following sex-steroid hormones: estradiol (E2), progesterone (P), testosterone (T)), non-sex hormones (thyroxin (fT4), thyroid-stimulating hormone (TSH) and prolactin (PRL), and the distribution of the ABO system phenotypic groups in the menopausal and postmenopausal women with breast tumors (benign, malignant). Enzyme-linked immunosorbent assay (ELISA) was used for quantitative determination of hormones. The immune-serological methods were used for investigation of the ABO system phenotypic groups. Our present investigations in menopausal and postmenopausal women with breast tumors have revealed significantly higher expression of sex-steroid hormone estradiol, but decreased progesterone, and also significantly increased testosterone levels. Thyroid gland revealed hypofunction, which confirms the decrease of thyroxin, and increase of prolactin and TSH in the blood. According to our findings, carriers of A(II) phenotypic groups showed high risk for breast tumors development in women during both stages, menopausal and postmenopausal.en_US
dc.identifier.affiliationsDepartment of Biology, Natural Science and Health Care, Batumi Shota Rustaveli State University, 6010 Batumi, Georgiaen_US
dc.identifier.affiliationsDepartment of Biology, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, 0186 Tbilisi, Georgiaen_US
dc.identifier.affiliationsLaboratory for Radiobiology and Molecular Genetics, “Vinca” Institute of Nuclear Sciences, University of Belgrade, 11001 Belgrade, Serbiaen_US
dc.identifier.affiliationsDepartment of Dentistry, Natural Science and Health Care, Batumi Shota Rustaveli State University, 6010 Batumi, Georgiaen_US
dc.identifier.affiliationsDepartment of Gynecologic Oncology, Florida Hospital Cancer Institute, Orlando, FL 32804, USAen_US
dc.identifier.citationKoridze Marina, Baratashvili Davit, Khukhunaishvili Rusudan, Nakashidze Irina, Petrovic Nina, Nagervadze Marina, Zosidze Nato, Tskvitinidze Sophiko, Kotrikadze Nanuli, Ahmad Sarfraz. Proteomic investigation of the molecular mechanism of king cobra venom L-amino acid oxidase induced apoptosis of human breast cancer (MCF-7) cell line. Indian Journal of Experimental Biology. 2018 Feb; 56(2): 101-111en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/190916
dc.languageenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.issuenumber2en_US
dc.relation.volume56en_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/43552en_US
dc.titleHormonal status and distribution of the ABO system phenotypic groups in menopausal and postmenopausal women with breast tumorsen_US
dc.typeJournal Articleen_US
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