A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21).
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Date
2008-01
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Abstract
t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphase results of AML-ETO fusion was positive and trisomy of 4 was confirmed with WCP probes. Trisomy 4 in AML with t(8;21) is a rare numerical abnormality. Here we present such case of patient which may constitute a distinctive subtype.
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Keywords
Acute myeloid leukemia, cytogenetics, fluorescence in situ hybridization
Citation
Trivedi P J, Patel P S, Brahmbhatt M M, Patel B P, Gajjar S B, Iyer R R, Parikh E H, Shukla S N, Shah P M, Bakshi S R. A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21). Indian Journal of Human Genetics. 2008 Jan; 14(1): 20-22.