Is the Total Score of the Hamilton Depression Rating Scale Associated with Suicide Attempts or Suicides.

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dc.contributor.authorJakobsen, Janus Christian
dc.contributor.authorSimonsen, Erik
dc.contributor.authorRasmussen, Kirsten Buch
dc.contributor.authorGluud, Christian
dc.date.accessioned2015-08-31T09:42:14Z
dc.date.available2015-08-31T09:42:14Z
dc.date.issued2013-01
dc.description.abstractBackground: Most evidence behind interventions for depression is, in essence, based on the total score of the 17-item Hamilton Depression Rating Scale (HDRS). We identified no systematic review or meta-analysis examining if a total 17-item HDRS score is associated with suicide attempts or suicides in depressive patients. Methodology: Based on a systematic literature search CENTRAL in The Cochrane Library, MEDLINE, EMBASE, PsycInfo, and Science Citation Index Expanded, we systematically reviewed and meta-analysed observational studies examining if the total 17-item HDRS score is associated with suicide attempts or suicides. Results: We identified and included ten cohort studies - seven retrospective and three prospective. All the studies were assessed as high risk of bias. Meta-analysis on the HDRS scores from three retrospective studies showed that depressive patients with a suicide attempt during the on-going depressive episode had a significantly higher score on the HDRS compared to non-suicidal patients (mean difference 6.31 HDRS; 95% confidence interval 4.72 to 7.91; P<0.00001, I2=0). However, meta-analyses of the HDRS scores from three prospective studies and four studies reporting retrospectively lifetime suicide attempts showed no significant differences between patients with or without a suicide attempt or suicide. Conclusion: A total score on the HDRS does not seem to be associated with past or future suicide attempts or suicides. There seems to be a need for other assessment tools to predict and explain risks of suicidality.en_US
dc.identifier.citationJakobsen Janus Christian, Simonsen Erik, Rasmussen Kirsten Buch, Gluud Christian. Is the Total Score of the Hamilton Depression Rating Scale Associated with Suicide Attempts or Suicides. British Journal of Medicine and Medical Research. 2013 Jan-Mar; 3(1): 140-152.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162798
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/810en_US
dc.subjectHamiltonen_US
dc.subjectpredictorsen_US
dc.subjectsuicideen_US
dc.subjectsuicidal tendenciesen_US
dc.subjectdepressionen_US
dc.subjectobservational studiesen_US
dc.subjectsystematic reviewen_US
dc.subjectmeta-analysisen_US
dc.titleIs the Total Score of the Hamilton Depression Rating Scale Associated with Suicide Attempts or Suicides.en_US
dc.typeArticleen_US
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