Dose-dependent response of central dopaminergic systems to metoclopramide in mice.

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dc.contributor.authorBhosale, K Ben_US
dc.contributor.authorBalsara, J Jen_US
dc.contributor.authorGaonkar, R Ken_US
dc.contributor.authorBhosale, B Ben_US
dc.contributor.authorGupta, S Ken_US
dc.date.accessioned2009-05-28T15:20:44Z
dc.date.available2009-05-28T15:20:44Z
dc.date.issued1997-06-01en_US
dc.description.abstractMetoclopramide (5 to 40 mg/kg, i.p.) induces catalepsy and antagonised apomorphine induced cage climbing behaviour in mice. This further indicate its postsynaptic striatal and mesolimbic D 2 dopamine (DA) receptor blocking activity. Metoclopramide at 1.25 and 2.5 mg/kg, i.p. induced stereotyped cage climbing behaviour in mice. Pretreatment with haloperidol and alpha-methyl-p-tyrosine significantly antagonised metoclopramide (1.25 and 2.5 mg/kg)-induced stereotyped cage climbing behaviour. Metoclopramide at these doses induces stereotyped cage climbing behaviour by releasing DA from the mesolimbic dopaminergic neurons with resultant activation of the postsynaptic mesolimbic D 2 DA receptors by the released DA. DA releasing action of metoclopramide (1.25 and 2.5 mg/kg, i.p.) and the subsequent induction of the stereotyped cage climbing behaviour by these doses of metoclopramide is explained on the basis of selective blockade of the presynaptic D 2 DA autoreceptors by these doses of metoclopramide.en_US
dc.description.affiliationDepartment of Pharmacology, Krishna Institute of Medical Sciences, Karad, India.en_US
dc.identifier.citationBhosale KB, Balsara JJ, Gaonkar RK, Bhosale BB, Gupta SK. Dose-dependent response of central dopaminergic systems to metoclopramide in mice. Indian Journal of Experimental Biology. 1997 Jun; 35(6): 618-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61864
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntiemetics --pharmacologyen_US
dc.subject.meshCentral Nervous System --drug effectsen_US
dc.subject.meshDopamine Antagonists --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshMaleen_US
dc.subject.meshMetoclopramide --pharmacologyen_US
dc.subject.meshMiceen_US
dc.titleDose-dependent response of central dopaminergic systems to metoclopramide in mice.en_US
dc.typeJournal Articleen_US
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