Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats.

Simple item page
dc.contributor.authorSingh, Jen_US
dc.contributor.authorGarg, K Nen_US
dc.contributor.authorMehrotra, G Cen_US
dc.date.accessioned2009-05-28T11:50:33Z
dc.date.available2009-05-28T11:50:33Z
dc.date.issued1990-12-01en_US
dc.description.abstractLiver necrosis was produced in rats by administering 3 doses of a mixture of carbon tetrachloride + olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aspartate and glutamate administration (100 mg/kg, ip) significantly reduced these elevated levels of AST, ALT, and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in aspartate and glutamate pretreated animals as observed macroscopically and histologically.en_US
dc.description.affiliationDepartment of Pharmacology and Pathology, Medical College, Rohtak, India.en_US
dc.identifier.citationSingh J, Garg KN, Mehrotra GC. Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats. Indian Journal of Experimental Biology. 1990 Dec; 28(12): 1180-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57274
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspartic Acid --therapeutic useen_US
dc.subject.meshCarbon Tetrachloride --antagonists & inhibitorsen_US
dc.subject.meshGlutamates --therapeutic useen_US
dc.subject.meshLiver Diseases --chemically induceden_US
dc.subject.meshMaleen_US
dc.subject.meshNecrosis --chemically induceden_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleEffect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology