Effect of T. indica and T. arjuna on Hematological Parameters in Rats Exposed to Fluoride

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dc.contributor.authorChourasia, A.en_US
dc.contributor.authorSharma, R.K.en_US
dc.contributor.authorShrman, K.en_US
dc.contributor.authorMishra, A.en_US
dc.contributor.authorGupta, V.en_US
dc.contributor.authorDubey, A.en_US
dc.date.accessioned2025-05-12T09:41:21Z
dc.date.available2025-05-12T09:41:21Z
dc.date.issued2024-10
dc.description.abstractExcessive fluoride intake is found toxic to the body. It is a highly soluble salt, ubiquitously present in water and its contamination in drinking water poses a public health problem, needs immediate attention. Since oxidative damage is the main cause of fluoride toxicity, the antioxidant potential of tamarind and arjuna having many anti-oxidant phyto-chemicals, may be exploited for the amelioration of its toxicity. This study aims to evaluate the renoprotective effect of Tamarindus indica and Terminalia arjuna on hematology in rats exposed to sodium fluoride. The experimental groups included: (I) control, (II) NaF (100ppm in drinking water for 56 days), (III) NaF@ 100 ppm and extract of T. indica @ 200 mg/kg b.w. orally for 56 days, (IV) NaF @ 100 ppm and T. arjuna extract @50 mg/kg b.w. orally, (V) NaF @ 100 ppm, extract of Tamarindus indica @ 100 mg/kg b.w. orally and T. arjuna @ 25 mg/kg b.w. orally for 56 days, (VI) Ascorbic acid @ 100 mg/kg b.w. orally and NaF@ 100 ppm for 56 days. Blood samples were collected at different intervals. Haemoglobin, total leucocyte count, differential leucocyte count and total erythrocyte count were estimated. Compared to the control group, the fluoride-treated group showed significant differences in hematological parameter, including decrease in lymphocyte percentage. The group that received ascorbic acid showed significant increase in the lymphocyte percentage of the fluoride-exposed rats when compared to group II. The rats treated with T. indica and T. arjuna, separately and in combination, showed a numerical increase in lymphocyte percentage when compared to group II.en_US
dc.identifier.affiliationsDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur, (M.P.), INDIAen_US
dc.identifier.affiliationsDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur, (M.P.), INDIAen_US
dc.identifier.affiliationsDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur, (M.P.), INDIAen_US
dc.identifier.affiliationsDepartment of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur, (M.P.), INDIAen_US
dc.identifier.affiliationsDepartment of Veterinary Microbiology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur, (M.P.), INDIAen_US
dc.identifier.affiliationsDepartment of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur, (M.P.), INDIAen_US
dc.identifier.citationChourasia A., Sharma R.K., Shrman K., Mishra A., Gupta V., Dubey A. . Effect of T. indica and T. arjuna on Hematological Parameters in Rats Exposed to Fluoride. Journal of Animal Research. 2024 Oct; 14(5): 301-306en_US
dc.identifier.issn2249-6629
dc.identifier.issn2277-940X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247434
dc.languageenen_US
dc.publisherThe Association of Mastitisen_US
dc.relation.issuenumber5en_US
dc.relation.volume14en_US
dc.source.urihttps://www.doi.org/10.30954/2277-940X.05.2024.1en_US
dc.subjectTamarindus indicaen_US
dc.subjectTerminalia arjunaen_US
dc.subjectsodium fluorideen_US
dc.subjectratsen_US
dc.subjectblooden_US
dc.titleEffect of T. indica and T. arjuna on Hematological Parameters in Rats Exposed to Fluorideen_US
dc.typeJournal Articleen_US
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