Impaired Fasting Glucose & 8-Iso- Prostaglandin F2a in Diabetes Disease Progression.

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dc.contributor.authorJelinek Herbert F
dc.contributor.authorJamil Dina A
dc.contributor.authorAubaidy Hayder A Al
dc.date.accessioned2016-03-11T05:07:34Z
dc.date.available2016-03-11T05:07:34Z
dc.date.issued2014-11-21
dc.description.abstractAims: The objective of the present study was to evaluate the changes of 8- isoprostaglandin F2α and other markers of oxidative stress with impaired fasting glucose when compared to non-diabetic control participants. Methodology: This is a cross-sectional study, conducted at Charles Sturt University, Albury, NSW, Australia and included 428 participants (female: male, 247:181) participants attending the Diabetes Complications Clinic in the School of Community Health for the period between January 2011 to October 2012. Results: Urinary 8-isoprostaglandin F2α was significantly greater in the impaired fasting glucose group (1.4±1.3ng/ml) compared to control group (0.68±0.5ng/ml, P= .05). The increase in urinary 8-isoprostaglandin F2α was associated with a significant elevation in serum total cholesterol (4.7±1.1mol/L, P= .04) and a significant reduction in high density lipoprotein cholesterol (1.4±0.4mmol/L, P= .02) in the impaired fasting glucose group compared to the control group. A significant negative correlation was noted between urinary 8-isoprostaglandin F2α and high-density lipoprotein cholesterol among all the participants included in this study (P= .05). Conclusions: The current study proves the importance of measuring markers of oxidative stress, expressed by urinary 8-isoprostaglandin F2α and serum lipids in managing cases of impaired fasting glucose and suggests a useful biomarker for assessing disease progression and/or remission, especially in the prediabetic state.en_US
dc.identifier.citationJelinek Herbert F,Jamil Dina A, Aubaidy Hayder A Al. Impaired Fasting Glucose & 8-Iso- Prostaglandin F2a in Diabetes Disease Progression. British Journal of Medicine and Medical Research. 2014 Nov; 4(33): 5229-5237.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/175676
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/5383en_US
dc.subjectOxidative stressen_US
dc.subjectimpaired fasting glucoseen_US
dc.subject8-isoprostaglandin F2αen_US
dc.subjectserum lipidsen_US
dc.titleImpaired Fasting Glucose & 8-Iso- Prostaglandin F2a in Diabetes Disease Progression.en_US
dc.typeArticleen_US
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