Effects of fluoride and ethanol administration on lipid peroxidation systems in rat brain.
dc.contributor.author | Chauhan, Shailender Singh | |
dc.contributor.author | Ojha, Sudarshan | |
dc.contributor.author | Mahmood, Akhtar | |
dc.date.accessioned | 2013-07-30T09:57:47Z | |
dc.date.available | 2013-07-30T09:57:47Z | |
dc.date.issued | 2013-03 | |
dc.description.abstract | Exposure to fluoride and excessive ethanol consumption has been identified as a serious public health problem in many parts of the world, including India. Thus, the effect of co-exposure to fluoride and ethanol for 3-6 weeks was studied on lipid peroxidation (LPO) and oxidative stress related parameters in the rat brain. After 3 weeks, co-treated animals showed 95% increase in LPO levels compared to control. However, the levels of reduced glutathione, total and protein thiols were decreased. These changes were accompanied by a decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase. Rats exposed to fluoride together with ethanol for 6 weeks resulted in 130% increase in LPO and decrease in the reduced glutathione levels. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase were reduced under these conditions. Brain histology revealed excessive lymphocytes, edema and spongeosis in the cortical region after six weeks of fluoride and ethanol treatment. These results suggest that exposure to fluoride together with ethanol enhances lipid peroxidation by affecting antioxidant defence systems in the rat brain. | en_US |
dc.identifier.citation | Chauhan Shailender Singh, Ojha Sudarshan, Mahmood Akhtar. Effects of fluoride and ethanol administration on lipid peroxidation systems in rat brain. Indian Journal of Experimental Biology. 2013 Mar; 51(3): 249-255. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/147589 | |
dc.language.iso | en | en_US |
dc.source.uri | https://nopr.niscair.res.in/handle/123456789/16122 | en_US |
dc.subject | Co-exposure | en_US |
dc.subject | Ethanol | en_US |
dc.subject | Fluoride | en_US |
dc.subject | Lipid peroxidation | en_US |
dc.subject | Rat brain | en_US |
dc.subject.mesh | Animals | |
dc.subject.mesh | Antioxidants --metabolism | |
dc.subject.mesh | Brain --drug effects | |
dc.subject.mesh | Ethanol --pharmacology | |
dc.subject.mesh | Fluorides --pharmacology | |
dc.subject.mesh | Free Radicals | |
dc.subject.mesh | Glutathione Peroxidase --metabolism | |
dc.subject.mesh | Glutathione Reductase --metabolism | |
dc.subject.mesh | Glutathione Transferase --metabolism | |
dc.subject.mesh | Lipid Peroxidation --drug effects | |
dc.subject.mesh | Male | |
dc.subject.mesh | Oxidative Stress | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Sprague-Dawley | |
dc.subject.mesh | Sodium Fluoride --pharmacology | |
dc.subject.mesh | Time Factors | |
dc.title | Effects of fluoride and ethanol administration on lipid peroxidation systems in rat brain. | en_US |
dc.type | Article | en_US |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijeb2013v51n3p249.pdf
- Size:
- 511.03 KB
- Format:
- Adobe Portable Document Format
- Description:
- Journal article
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: