Effects of fluoride and ethanol administration on lipid peroxidation systems in rat brain.

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dc.contributor.authorChauhan, Shailender Singh
dc.contributor.authorOjha, Sudarshan
dc.contributor.authorMahmood, Akhtar
dc.date.accessioned2013-07-30T09:57:47Z
dc.date.available2013-07-30T09:57:47Z
dc.date.issued2013-03
dc.description.abstractExposure to fluoride and excessive ethanol consumption has been identified as a serious public health problem in many parts of the world, including India. Thus, the effect of co-exposure to fluoride and ethanol for 3-6 weeks was studied on lipid peroxidation (LPO) and oxidative stress related parameters in the rat brain. After 3 weeks, co-treated animals showed 95% increase in LPO levels compared to control. However, the levels of reduced glutathione, total and protein thiols were decreased. These changes were accompanied by a decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase. Rats exposed to fluoride together with ethanol for 6 weeks resulted in 130% increase in LPO and decrease in the reduced glutathione levels. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase were reduced under these conditions. Brain histology revealed excessive lymphocytes, edema and spongeosis in the cortical region after six weeks of fluoride and ethanol treatment. These results suggest that exposure to fluoride together with ethanol enhances lipid peroxidation by affecting antioxidant defence systems in the rat brain.en_US
dc.identifier.citationChauhan Shailender Singh, Ojha Sudarshan, Mahmood Akhtar. Effects of fluoride and ethanol administration on lipid peroxidation systems in rat brain. Indian Journal of Experimental Biology. 2013 Mar; 51(3): 249-255.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147589
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/16122en_US
dc.subjectCo-exposureen_US
dc.subjectEthanolen_US
dc.subjectFluorideen_US
dc.subjectLipid peroxidationen_US
dc.subjectRat brainen_US
dc.subject.meshAnimals
dc.subject.meshAntioxidants --metabolism
dc.subject.meshBrain --drug effects
dc.subject.meshEthanol --pharmacology
dc.subject.meshFluorides --pharmacology
dc.subject.meshFree Radicals
dc.subject.meshGlutathione Peroxidase --metabolism
dc.subject.meshGlutathione Reductase --metabolism
dc.subject.meshGlutathione Transferase --metabolism
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshMale
dc.subject.meshOxidative Stress
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshSodium Fluoride --pharmacology
dc.subject.meshTime Factors
dc.titleEffects of fluoride and ethanol administration on lipid peroxidation systems in rat brain.en_US
dc.typeArticleen_US
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