Anti-atherosclerotic effect of atorvastatin and clopidogrel alone and in combination in rats.

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dc.contributor.authorSrinivas, Marthaen_US
dc.contributor.authorAnnapurna, Akulaen_US
dc.contributor.authorReddy, Yellu Narsimhaen_US
dc.date.accessioned2009-05-28T13:30:31Z
dc.date.available2009-05-28T13:30:31Z
dc.date.issued2008-10-26en_US
dc.description.abstractAtherosclerosis is a disease affecting arterial blood vessels due to the accumulation of macrophage white blood cells and low density lipoproteins. Effects of atorvastatin, a recently introduced lipid lowering statin was studied alone and in combination with clopidogrel in high fat diet fed atherosclerotic rats orally. Results showed significant reduction in total serum cholesterol and malondialdehyde levels and significant improvement in urine creatinine levels. Aortic cross sections of rats treated with clopidogrel alone showed reversal of atherosclerotic calcification. The same effect was observed with the combined treatment of clopidogrel and atorvastatin. Only atorvastatin treatment did not show any histological atheroprotective effect. Atorvastatin and clopidogrel alone and in combination have offered significant atheroprotective effect. No specific advantage was seen with combined treatment of atorvastatin and clopidogrel, moreover the advantages seen with independent drug administration also reduced with combined treatment.en_US
dc.description.affiliationPharmacology Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India.en_US
dc.identifier.citationSrinivas M, Annapurna A, Reddy YN. Anti-atherosclerotic effect of atorvastatin and clopidogrel alone and in combination in rats. Indian Journal of Experimental Biology. 2008 Oct; 46(10): 698-703en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59500
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/4636/1/IJEB%2046%2810%29%20698-703.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtherosclerosis --blooden_US
dc.subject.meshDiet, Atherogenicen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeptanoic Acids --administration & dosageen_US
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshPlatelet Aggregation Inhibitors --administration & dosageen_US
dc.subject.meshPyrroles --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshTiclopidine --administration & dosageen_US
dc.titleAnti-atherosclerotic effect of atorvastatin and clopidogrel alone and in combination in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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