Antiatherogenic, Hypolipidemic and Antiinflammatory Benefits of Black Tea and Zanthoxylum Zanthoxyloid.
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Date
2014-03-21
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Abstract
The use of medicinal plants in the treatment of ailments is increasing around the globe.
This study assessed the antihyperlipidemic and antiatherogenic benefits of black tea
(BT) and Z. zanthoxylum (Zz) in rats. Thirty two albino rats were randomly divided into
eight groups each containing four animals. Group 1 normal control; animals in groups 2,
3 and 4 were fed standard diet supplemented with BT or ZZ or a combination of both at
equal amounts (3% each), respectively. Animals in group 5 are control rats, fed diet
supplemented with cholesterol and groundnut oil at a dose level of 100 g and 300g/25 kg
diet respectively. Rats in groups 6, 7 and 8 were fed the same high lipid diet but
supplemented with BT, Z.z or mixture of both respectively. Lipid enriched diet caused a
significant increase in total cholesterol, total lipids, and triacylglycerols in both serum and
liver. Serum phospholipids, LDL-C, and atherogenic index significantly increased
compared with normal control group. BT and Zz significantly increased fecal total lipids, total cholesterol and triacylglycerol levels as well as significantly increased serum
malondialdehyde, interleukin-2 and tumour necrosis factor-alpha compared to healthy
control. Consumption of black tea, Zanthoxylum zanthoxyloid or a combination mixture of
them by healthy and hyperlipidemic hypercholesterolemic rats resulted in significantly
decreased lipid parameters in serum and liver and significant reduced lipid peroxidation
and inflammation. These results suggest that both black tea and Zanthoxylum
zanthoxyloid had anti-atherogenic and hypolipidemic effects and reduced oxidative
stress via inhibition of inflammation and lipid peroxidation.
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Keywords
Natural products, antiatherogenic, hypolipidemic, cardiovascular disease, antiinflammatory, antioxidation
Citation
Sanmi Adekunle Adeniran, Oluba A, Jonathan Babatola Leye, Paul Kamdem John, Adesokan A. Antiatherogenic, Hypolipidemic and Antiinflammatory Benefits of Black Tea and Zanthoxylum Zanthoxyloid. British Journal of Medicine and Medical Research. 2014 Mar; 4(9): 1923-1937.