Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice.

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dc.contributor.authorRajendran, N Nen_US
dc.contributor.authorThirugnanasambandam, Pen_US
dc.contributor.authorParvathavarthini, Sen_US
dc.contributor.authorViswanathan, Sen_US
dc.contributor.authorRamaswamy, Sen_US
dc.date.accessioned2009-05-28T13:35:48Z
dc.date.available2009-05-28T13:35:48Z
dc.date.issued2001-10-09en_US
dc.description.abstractThe present study investigated the cause effect relationship between glycemic and algesic states. The hypo- and hyperglycemic conditions were induced physiologically through exercise (3 min swim at room temperature 28 degrees - 30 degrees C) and external dextrose (2 g/kg, ip) administration respectively in mice. Besides, flavone (50 mg/kg, sc) a known antinociceptive drug was chosen to study such a cause effect relationship. The anti-nociception was assessed by acetic acid assay, blood glucose measured using glucometer (Ames) and serum insulin by radioimmunoassay. The findings revealed that irrespective of the glycemic state whether hypo-, hyper, or euglycemic induced by swim stress, dextrose or flavone per se respectively, significant antinociceptive response was recorded. Pretreatment with flavone (50 mg/kg, sc) always exhibited a tendency to reverse the hyperglycemia, if any, but enhanced the antinociceptive response either after swim stress or after dextrose. These data support the contention that changes in the glycemic state in acute condition is not responsible for antinociceptive response and thereby suggesting dissociation between these two parameters. Extended studies estimating serum insulin level after the above mentioned maneuvers showed a significant rise whenever antinociceptive response was recorded irrespective of the glycemic state. It is suggested that serum insulin level, a hormonal parameter rather than the blood glucose level, which is a metabolic parameter, appears more reliable. It appears that the changes in serum insulin level produced by various treatments may have a relationship with the antinociceptive response. However, this study has the limitation that the results can apply only for acute conditions and extrapolation to clinical conditions is debatable.en_US
dc.description.affiliationInstitute of Pharmacology, Madras Medical College and Research Institute, Chennai, India.en_US
dc.identifier.citationRajendran NN, Thirugnanasambandam P, Parvathavarthini S, Viswanathan S, Ramaswamy S. Modulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice. Indian Journal of Experimental Biology. 2001 Oct; 39(10): 1009-16en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59617
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetic Acid --toxicityen_US
dc.subject.meshAnalgesics --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose --physiologyen_US
dc.subject.meshFlavonoids --pharmacologyen_US
dc.subject.meshGlucose --pharmacologyen_US
dc.subject.meshHyperglycemia --physiopathologyen_US
dc.subject.meshHypoglycemia --physiopathologyen_US
dc.subject.meshInsulin --physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshNaloxone --pharmacologyen_US
dc.subject.meshNarcotic Antagonists --pharmacologyen_US
dc.subject.meshPain --chemically induceden_US
dc.subject.meshPain Threshold --physiologyen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshSwimmingen_US
dc.titleModulation by insulin rather than blood glucose of the pain threshold in acute physiological and flavone induced antinociception in mice.en_US
dc.typeJournal Articleen_US
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