Identification of hydroxyl radicals after UV irradiation of aqueous extracts of cigarette smoke and evaluation of urinary 8-OHdG in smokers.

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dc.contributor.authorYatsuzuka, Mikien_US
dc.contributor.authorTazawa, Kenjien_US
dc.contributor.authorYasuda, Tomomien_US
dc.contributor.authorYoshii, Mihoen_US
dc.contributor.authorOgawa, Kouheien_US
dc.contributor.authorWada, Shigetoen_US
dc.date.accessioned2009-05-27T17:40:12Z
dc.date.available2009-05-27T17:40:12Z
dc.date.issued2004-07-18en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractThe role of oxidative stress in tobacco smoke damage was examined using a combination of in vitro and in vivo approaches. Aqueous extracts of cigarette smoke were irradiated with UV and hydroxyl radical generation was evaluated by electron spin resonance (ESR). The spectra obtained revealed spin adducts of the hydroxyl radical (*OH) to increase with the volume of the aqueous extract of cigarette smoke, cigarette smoke collection flow, and UV irradiation time. Hydroxyl radical generation persisted for long hours, showing no change over time. Ascorbic acid protected against radical generation in a marked concentration-dependent fashion. In specimens of urine from volunteers, 8-OHdG levels and the 8-OHdG-production rate per hour were found to be higher in smokers than non-smokers. Our results suggest that more marked oxidative stress occurs with the smoking habit.en_US
dc.description.affiliationDepartment of Adult Nursing (Acute Stage), Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.en_US
dc.identifier.citationYatsuzuka M, Tazawa K, Yasuda T, Yoshii M, Ogawa K, Wada S. Identification of hydroxyl radicals after UV irradiation of aqueous extracts of cigarette smoke and evaluation of urinary 8-OHdG in smokers. Asian Pacific Journal of Cancer Prevention. 2004 Jul-Sep; 5(3): 279-83en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37638
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAntioxidants --pharmacologyen_US
dc.subject.meshAscorbic Acid --pharmacologyen_US
dc.subject.meshDNA Damageen_US
dc.subject.meshDeoxyguanosine --analogs & derivativesen_US
dc.subject.meshElectron Spin Resonance Spectroscopyen_US
dc.subject.meshFree Radicals --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshSmoking --adverse effectsen_US
dc.subject.meshUltraviolet Raysen_US
dc.titleIdentification of hydroxyl radicals after UV irradiation of aqueous extracts of cigarette smoke and evaluation of urinary 8-OHdG in smokers.en_US
dc.typeJournal Articleen_US
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