Evaluation of the antibacterial activity of Coccinia grandis, against bacteria isolated from chronic suppurative otitis media infection

Simple item page
dc.contributor.authorDubey, Den_US
dc.contributor.authorSwain, SKen_US
dc.contributor.authorLenka, Sen_US
dc.contributor.authorMeher, RKen_US
dc.contributor.authorKar, Ben_US
dc.contributor.authorRath, S.en_US
dc.date.accessioned2024-11-30T06:00:47Z
dc.date.available2024-11-30T06:00:47Z
dc.date.issued2023-01
dc.description.abstractThis present study evaluates the in vitro antimicrobial activity of the selected Indian medicinal plant Coccinia grandis (C. grandis) against this isolated multidrug-resistant bacteria causing chronic suppurative otitis media infection (CSOM) along with their in vivo toxicity test using a rat model. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of the effective leaf extract were measured using the micro broth dilution method. Out of 128 samples, 79 samples were identified as positive for bacterial infection. Out of six solvent extracts of C. grandis methanol and ethyl acetate, leaf extracts have shown the best antimicrobial activities compared to the rest of the four solvent extracts. Methanolic extract 1.56 mg/ml and 0.78 mg/ml was the MIC values for the respective plants. Staphylococcus aureus and Pseudomonas aeruginosa species are the most common bacterial isolates in CSOM infection. Hence, the causative organism and its drug sensitivity pattern should be carried out before treatment. Due to increasing cases of antibiotic resistance among bacteria, an alternative therapy is the need of the day, especially regarding the needier population with lesser toxicity. Hence, plants can be used as a choice of drugs to treat CSOM infection.en_US
dc.identifier.affiliationsMedical Research Laboratory, IMS and SUM Hospital, Siksha ‘O’ Anusandhan Deemed to be University, K8, Kalinga Nagar, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Otorhinolaryngology and Head and Neck Surgery, IMS and SUM Hospital, Siksha ‘O’ Anusandhan Deemed to be University, K8, Kalinga Nagar, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Otorhinolaryngology and Head and Neck Surgery, IMS and SUM Hospital, Siksha ‘O’ Anusandhan Deemed to be University, K8, Kalinga Nagar, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology and Bioinformatics, Sambalpur University, Jyotivihar, Burla, Sambalpur, Odisha, Indiaen_US
dc.identifier.affiliationsSchool of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha,Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology and Research, Central Research Laboratory, Institute of Dental Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.en_US
dc.identifier.citationDubey D, Swain SK, Lenka S, Meher RK, Kar B, Rath S.. Evaluation of the antibacterial activity of Coccinia grandis, against bacteria isolated from chronic suppurative otitis media infection. Journal of Applied Biology & Biotechnology. 2023 Jan; 11(1): 139-145en_US
dc.identifier.issn2473-7005
dc.identifier.issn2347-212X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/236516
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber1en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.7324/JABB.2023.110119en_US
dc.subjectAntibiotic resistanceen_US
dc.subjectChronic suppurative otitis media infectionen_US
dc.subjectIn vivo toxicity analysisen_US
dc.subjectMinimum bactericidal concentrationen_US
dc.subjectMinimum inhibitory concentration.en_US
dc.titleEvaluation of the antibacterial activity of Coccinia grandis, against bacteria isolated from chronic suppurative otitis media infectionen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
jabb2023v11n1p139.pdf
Size:
1.53 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Applied Biology & Biotechnology