6 Paths of ERK5 signaling pathway regulate hepatocyte proliferation in rat liver regeneration.

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dc.contributor.authorLi, Zhanpeng
dc.contributor.authorCheng, Zhenchao
dc.contributor.authorWang, Gaiping
dc.contributor.authorHao, Xioxia
dc.contributor.authorZhang, Lijun
dc.contributor.authorXu, Cunshuan
dc.date.accessioned2012-08-10T06:07:56Z
dc.date.available2012-08-10T06:07:56Z
dc.date.issued2012-06
dc.description.abstractGenerally, extra-cellular-signal-regulated kinase 5 (ERK5) signaling pathway regulates many physiological activities, such as cell proliferation and cell differentiation. However, little is known about how ERK5 signaling pathway composed of 15 paths participates in regulating hepatocyte proliferation during liver regeneration (LR). In this study, to explore the influence ERK5 signaling pathway upon hepatocytes at gene transcription level, rat genome 230 2.0 array was used to detect expression changes of 75 related genes in isolated hepatocytes from rat regenerating liver. Bioinformatics and systems biology methods were applied to analyze the precise role of ERK5 signaling pathway in regulating hepatocyte proliferation during LR. Results showed that 62 genes were contained in the array and 22 genes were significantly changed. It was found that 6 paths were related to hepatocyte proliferation during rat LR. Among them, paths 3, 6 and 13 of ERK5 signaling pathway modulated cell cycle progression by decreasing the negative influence on ERK5 and paths 3, 4, 8 and 9 by reinforcing the positive influence on ERK5. In summary, the study shows that 22 genes and 6 paths of ERK5 signaling pathway participate in regulating proliferation of hepatocytes in rat LR.en_US
dc.identifier.citationLi Zhanpeng, Cheng Zhenchao, Wang Gaiping, Hao Xioxia, Zhang Lijun, Xu Cunshuan. 6 Paths of ERK5 signaling pathway regulate hepatocyte proliferation in rat liver regeneration. Indian Journal of Biochemistry & Biophysics. 2012 Jun; 49(3): 165-172.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/140232
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/14276en_US
dc.subjectERK5 signaling pathwayen_US
dc.subjectRat liver regenerationen_US
dc.subjectHepatocyte proliferationen_US
dc.subjectRat genome 230 2.0 arrayen_US
dc.subjectGene expression profilesen_US
dc.subject.meshAnimals
dc.subject.meshCell Growth Processes --genetics
dc.subject.meshCell Growth Processes --physiology
dc.subject.meshGene Expression Profiling --methods
dc.subject.meshHepatectomy
dc.subject.meshHepatocytes --cytology
dc.subject.meshHepatocytes --enzymology
dc.subject.meshHepatocytes --physiology
dc.subject.meshLiver Regeneration --genetics
dc.subject.meshLiver Regeneration --physiology
dc.subject.meshMAP Kinase Signaling System --genetics
dc.subject.meshMAP Kinase Signaling System --physiology
dc.subject.meshMitogen-Activated Protein Kinase 7 --genetics
dc.subject.meshMitogen-Activated Protein Kinase 7 --metabolism
dc.subject.meshOligonucleotide Array Sequence Analysis --methods
dc.subject.meshRandom Allocation
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.title6 Paths of ERK5 signaling pathway regulate hepatocyte proliferation in rat liver regeneration.en_US
dc.typeArticleen_US
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