Nutrient and Bioactive Components of Annona muricata and Fagara zanthoxyloide of South-Southern Nigeria

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dc.contributor.authorEkere, O. U.en_US
dc.contributor.authorC. C., Monago-Ighorodjeen_US
dc.contributor.authorOgunka-Nnoka, C. U.en_US
dc.date.accessioned2020-05-05T07:04:51Z
dc.date.available2020-05-05T07:04:51Z
dc.date.issued2020-04
dc.description.abstractIntroduction:Prediabetes is associated with dysglycemia, endothelial dysfunction,obesity and inflammation, placing them at an increased risk of cardiovascular events.Aims: The present study aimed to investigate the risk of cardiovascular disease associated with prediabetes by estimation of serum interleukin-6, myeloperoxidase and urine microalbumin and their correlation with fasting plasma glucose and anthropometric measurements.Study Design:Cross sectional study.Place and Duration of Study: Study was conducted at Department of Biochemistry, Kasturba Medical College Hospitals, Mangaluru between 2014 and 2015.Methodology:Eighty subjects were categorised into prediabetes and healthy controls based on their fasting plasma glucose values. Anthropometric data (weight, body mass index, waist circumference, hip circumference and waist-to-hip ratio from all subjects were recorded. Interleukin-6 & myeloperoxidase were estimated in serum sample whereas microalbumin was estimated in random urine sample Results:The mean anthropometric measurements and cardiovascular disease risk markers (interleukin-6, myeloperoxidase and urine microalbumin) were found to be significantly higher (p < 0.05) in prediabetes group. Myeloperoxidase had significant correlation with fasting plasma glucose (r-0.388) in the prediabetes group. Interleukin-6 and myeloperoxidase also showed a positive correlation with body mass index (r -0.339, r -0.327), waist circumference (r -484, r -0.493) and waist-to-hip ratio (r -0.430, r -0.493) while urine microalbumin did not correlate with fasting plasma glucose and anthropometric measurements in prediabetes group.Conclusion:This study suggests that prediabetes is associated with central adiposity and have an increased risk for cardiovascular disease.en_US
dc.identifier.affiliationsDepartment of Biochemistry, University of Port Harcourt, Nigeria.*en_US
dc.identifier.citationEkere O. U., C. C. Monago-Ighorodje, Ogunka-Nnoka C. U. . Nutrient and Bioactive Components of Annona muricata and Fagara zanthoxyloide of South-Southern Nigeria . International Journal of Biochemistry Research & Review. 2020 Apr; 29(2): 41-47en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200779
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume29en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2020/v29i2/30171en_US
dc.subjectAnnona muricataen_US
dc.subjectFagara zanthoxyloideen_US
dc.subjectmineralsen_US
dc.subjectvitaminsen_US
dc.subjectphytochemicalsen_US
dc.titleNutrient and Bioactive Components of Annona muricata and Fagara zanthoxyloide of South-Southern Nigeriaen_US
dc.typeJournal Articleen_US
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