Correlation of Body Mass Index with Serum Osteocalcin and Insulin-Like Growth Factor Binding Protein-3 in the Assessment of Pubertal Growth Spurt - A Comparative Study

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dc.contributor.authorKeerthana, SVen_US
dc.contributor.authorYezdani, Aen_US
dc.contributor.authorKannan, MSen_US
dc.contributor.authorPadmavathy, Ken_US
dc.date.accessioned2025-08-13T08:52:15Z
dc.date.available2025-08-13T08:52:15Z
dc.date.issued2025-03
dc.description.abstractIntroduction: Body Mass Index (BMI) percentiles have a bearing on skeletal maturation. The correlation of BMI with serum osteocalcin (OC) and insulin-like growth factor binding protein-3 (IGFBP-3) and cervical vertebral maturation (CVM) assumes even greater importance in orthodontic treatment planning for skeletal Class II jaw discrepancies. The aim of the study was thus to estimate BMI percentiles, serum OC, and IGFBP-3 and correlate it with CVM to assess the opportune pubertal growth spurt. Materials and Methods: Height and body weight were measured to the BMI percentiles of the study participants with skeletal class II malocclusion (n = 51, age 11–18 yrs). Lateral cephalometry was used for CVM staging. Blood was collected to quantitatively assess the serum OC and IGFBP-3 levels using Sandwich-ELISA. Results: Obesity was more common in females compared to males (24% vs. 7.69%) while the reverse was true for underweight (4% vs. 15.39%). The majority of the obese participants belonged to CVM4–CVM6. Mean OC and IGFBP-3 were the highest in the obese category (71.879 ± 5.275 ng/mL, 55.541 ± 5.795 ng/mL). No statistically significant difference was observed in the mean OC and IGFBP-3 levels between males and females (64.993 ± 10.929 ng/mL vs. 58.795 ± 23.054 ng/mL, P = 0.231: 44.030 ± 12.767 ng/mL vs. 48.081 ± 10.843 ng/mL, P = 0.229). Conclusion: The clinical relevance of serum biomarkers (OC, IGFBP-3) and their correlation with BMI percentile and CVM stages could be certainly used to assess the circumpubertal growth status. Obese and severely obese females, though they belong to the age range of 13–17 years and later CVM stages, there was a significant increase in OC and IGFBP-3 serum levels that could be used to plan orthopedic treatment.en_US
dc.identifier.affiliationsDepartment of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, India; Department of Orthodontics and Dentofacial Orthopedics, RVS Dental College and Hospital, The Tamil Nadu Dr. MGR Medical University, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationKeerthana SV, Yezdani A, Kannan MS, Padmavathy K.Correlation of Body Mass Index with Serum Osteocalcin and Insulin-Like Growth Factor Binding Protein-3 in the Assessment of Pubertal Growth Spurt - A Comparative Study.Indian Journal of Dental Research.2025 Mar;36(1):49-53en_US
dc.identifier.issn0970-9290
dc.identifier.issn1998-3603
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/250227
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.4103/ijdr.ijdr_266_24en_US
dc.subjectBiochemical skeletal maturity indicatorsen_US
dc.subjectbody mass indexen_US
dc.subjectcervical vertebraeen_US
dc.subjectpubertal growth spurten_US
dc.titleCorrelation of Body Mass Index with Serum Osteocalcin and Insulin-Like Growth Factor Binding Protein-3 in the Assessment of Pubertal Growth Spurt - A Comparative Studyen_US
dc.typeJournal Articleen_US
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