Current trends of Carbapenemase Production Amongst Multi-drug Resistant Gram-Negative Bacteria in a Tertiary-Care Hospital in West Bengal

Simple item page
dc.contributor.authorChakravarty, Arunimaen_US
dc.contributor.authorRay, Rajaen_US
dc.contributor.authorMondal, Ananda Sen_US
dc.contributor.authorRaj, Hirak J.en_US
dc.date.accessioned2025-08-13T09:33:18Z
dc.date.available2025-08-13T09:33:18Z
dc.date.issued2025-03
dc.description.abstractBackground: Carbapemase production, being encoded on plasmids, can lead to transferable resistance and outbreaks with a community/hospital setup.Objectives: Our aim was to study the prevalence of Carbapenemase producing multi-drug resistant gram-negative bacteria in different zones of our hospital to aid in antimicrobial resistance surveillance.Methods and Materials: All clinical samples sent for culture and sensitivity study during the study period were followed up for detection of Carbapenemase production by phenotypic tests such as Carbapenem Inactivation tests and Carba NP test. Subsequently, molecular testing was done by PCR using five gene targets - blaKPC, blaNDM, blaIMP, blaVIM, and blaOXA-48 .Results: The overall prevalence of Carbapenemase production among strains of Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii and Pseudomonas aeruginosa was 45.25%. Klebsiella pneumoniae was found to be the most common Carbapenemase producer (45%). Metallo-?-lactamase was the predominant phenotypic expression and the most common gene was NDM (74%). Conclusions: The high prevalence of Carbapenemase producing bacteria in intensive care zones is a cause of alarm. Early detection of resistance, stringent infection prevention and control measures and antimicrobial stewardship are essential to preserve the usefulness of Carbapenems and improve therapeutic outcomes in patients.en_US
dc.identifier.affiliationsDepartment of Microbiology, IPGMER & SSKM Hospital, Kolkata, West Bengal. Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, IPGMER & SSKM Hospital, Kolkata, West Bengal. Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, IPGMER & SSKM Hospital, Kolkata, West Bengal. Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, IPGMER & SSKM Hospital, Kolkata, West Bengal. Indiaen_US
dc.identifier.citationChakravarty Arunima, Ray Raja, Mondal Ananda S, Raj Hirak J. . Current trends of Carbapenemase Production Amongst Multi-drug Resistant Gram-Negative Bacteria in a Tertiary-Care Hospital in West Bengal . JK Science Journal of Medical Education and Research. 2025 Mar; 27(1): 43-48en_US
dc.identifier.issn0972-1177
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252433
dc.languageenen_US
dc.publisherDr. Annil Mahajan from Jammu (J&K), Indiaen_US
dc.relation.issuenumber1en_US
dc.relation.volume27en_US
dc.source.urihttps://journals.indexcopernicus.com/api/file/viewByFileId/2343087en_US
dc.subjectCarbapenem resistanceen_US
dc.subjectCarba NP testen_US
dc.subjectCarbapenemase productionen_US
dc.subjectNDMen_US
dc.subjectOXA-48.en_US
dc.titleCurrent trends of Carbapenemase Production Amongst Multi-drug Resistant Gram-Negative Bacteria in a Tertiary-Care Hospital in West Bengalen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
jksjmer2025v27n1p43.pdf
Size:
697.11 KB
Format:
Adobe Portable Document Format
Download
Collections
JK Science Journal of Medical Education and Research