Sildenafil Determination by Using UPLC in Different Italian Viagra Tablets.
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Date
2014-11
Journal Title
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Abstract
The introduction of generics drugs has brought the need for more control of their
quality and purity. In Italy from June 23, 2013 the Pfizer® has no longer the patent for the
Viagra’s production and other industries produce equivalent products containing Sildenafil
citrate.
Study design: Thus, in this work, the chemical profiles of both Viagra Italian Pfizer® and 3
Italian commercial Sildenafil citrate tables (generic pharmaceutical manufacturers) for
male erectile dysfunction were obtained by using UltraPerformanceLiquid
Chromatography (UPLC).
Methodology: UPLC methodology was successfully used for the assay of Sildenafil
citrate in different products in Italy which are under the cover of alternative systems of
medicine.
Results: The results show that: i) the chromatographic profiles obtained from Italian
Sildenafil citrate tablets are identical and not present other active pharmaceutical
ingredients; ii) the commercial samples have a quantity of Sildenafil citrate comparable
with the corresponding labelled amounts. Conclusion: The UPLC method can be used for determination of Sildenafil citrate tables
marketed by generic pharmaceutical manufacturers in Italy.
Description
Keywords
Chemical profile, UPLC, pharmaceutical preparations, sildenafil, stress testing, Viagra
Citation
Giarretta Nicola, Mezzacapo Maria C, Di Giuseppe Antonella M A, Landi Nicola, Lippert Martina, Maro Antimo Di. Sildenafil Determination by Using UPLC in Different Italian Viagra Tablets. International Journal of Biochemistry Research & Review 2014 Nov-Dec ; 4 (6) : 607-614.